Fibrinolyse intraventrikularer hamatome mit rt-PA

Translated title of the contribution: Fibrinolysis of intraventricular hematoma with tissue plasminogen activator

S. Schwarz, S. Schwab, H. H. Steiner, D. Hanley, W. Hacke

Research output: Contribution to journalArticlepeer-review

Abstract

Intraventricular administration of recombinant tissue plasminogen activator (rt-PA) is an experimental therapy to hasten the lysis of intraventricular hemorrhages. We report nine patients (7 male, 2 female, mean age 64a) with intracerebral hematoma with ventricular extension who were treated with intraventricular infusion of rt-PA (2-32 mg, mean dose 17 mg). In two patients, clinically significant bleeding complications were associated with the fibrinolytic therapy. In one of these patients, fibrinolytic therapy was stopped. Other complications could not be observed. In eight of all nine patients, a rapid and extensive reduction of the amount of intraventricular blood occurred. A persistent shunt became necessary in two patients. We conclude, that intraventricular fibrinolysis probably leads to a faster clearance of intraventricular blood. Despite of fibrinolytic treatment, a permanent shunt becomes necessary in some cases. Intraventricular fibrinolysis is a potentially hazardous therapy with the risks of bleeding complications and infection.

Translated title of the contributionFibrinolysis of intraventricular hematoma with tissue plasminogen activator
Original languageGerman
Pages (from-to)123-130
Number of pages8
JournalNervenarzt
Volume70
Issue number2
DOIs
StatePublished - Feb 1 1999

Keywords

  • Intracerebral hemorrhage
  • Intraventricular hemorrhage
  • Tissue plasminogen activator
  • Ventricular drainage

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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