Fibrin Sealant Reduces Perioperative Blood Loss in Total Hip Replacement

Gwo Jaw Wang, Charles A. Goldthwaite, Sandra Burks, Ross Crawford, William D. Spotnitz, David Hungerford, John Cardea, Robert Schmidt, Jeff Kugler, Thomas McCoy, Graham Gie, Michael Pearse, Gareth Thomas

Research output: Contribution to journalArticle

Abstract

Patients (n = 81) undergoing total hip replacement (THR) were randomized to receive either standard of care plus fibrin sealant (FS) (10 mL total) or standard of care alone to evaluate the efficacy of FS for reducing blood loss in THR. Considering the 81 intent-to-treat patients, adjusted perioperative blood loss was reduced significantly in the FS group, by 197 mL [95% CI: 45 mL, 319 mL] or 23.5% [95% CI:5.4%, 38.1%] (p = 0.014). When protocol violators were eliminated, leaving 73 patients, the adjusted FS group perioperative bleeding was reduced by 221 mL [95% CI: 63 mL, 351 mL] or 27.1% [95% CI: 7.6%, 42.5%] (p = 0.0098).

Original languageEnglish (US)
Pages (from-to)399-411
Number of pages13
JournalJournal of Long-Term Effects of Medical Implants
Volume13
Issue number5
DOIs
StatePublished - 2003

Fingerprint

Fibrin Tissue Adhesive
Hip Replacement Arthroplasties
Sealants
Blood
Standard of Care
Hemorrhage

Keywords

  • Fibrin sealant
  • Hemostasis
  • Total hip replacement

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Orthopedics and Sports Medicine
  • Pathology and Forensic Medicine

Cite this

Wang, G. J., Goldthwaite, C. A., Burks, S., Crawford, R., Spotnitz, W. D., Hungerford, D., ... Thomas, G. (2003). Fibrin Sealant Reduces Perioperative Blood Loss in Total Hip Replacement. Journal of Long-Term Effects of Medical Implants, 13(5), 399-411. https://doi.org/10.1615/JLongTermEffMedImplants.v13.i5.50

Fibrin Sealant Reduces Perioperative Blood Loss in Total Hip Replacement. / Wang, Gwo Jaw; Goldthwaite, Charles A.; Burks, Sandra; Crawford, Ross; Spotnitz, William D.; Hungerford, David; Cardea, John; Schmidt, Robert; Kugler, Jeff; McCoy, Thomas; Gie, Graham; Pearse, Michael; Thomas, Gareth.

In: Journal of Long-Term Effects of Medical Implants, Vol. 13, No. 5, 2003, p. 399-411.

Research output: Contribution to journalArticle

Wang, GJ, Goldthwaite, CA, Burks, S, Crawford, R, Spotnitz, WD, Hungerford, D, Cardea, J, Schmidt, R, Kugler, J, McCoy, T, Gie, G, Pearse, M & Thomas, G 2003, 'Fibrin Sealant Reduces Perioperative Blood Loss in Total Hip Replacement', Journal of Long-Term Effects of Medical Implants, vol. 13, no. 5, pp. 399-411. https://doi.org/10.1615/JLongTermEffMedImplants.v13.i5.50
Wang, Gwo Jaw ; Goldthwaite, Charles A. ; Burks, Sandra ; Crawford, Ross ; Spotnitz, William D. ; Hungerford, David ; Cardea, John ; Schmidt, Robert ; Kugler, Jeff ; McCoy, Thomas ; Gie, Graham ; Pearse, Michael ; Thomas, Gareth. / Fibrin Sealant Reduces Perioperative Blood Loss in Total Hip Replacement. In: Journal of Long-Term Effects of Medical Implants. 2003 ; Vol. 13, No. 5. pp. 399-411.
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