Fibrillary glomerulonephritis presenting as rapidly progressive glomerulonephritis

Purva Sharma, Michael Kuperman, Lorraine Racusen, Duvuru Geetha

Research output: Contribution to journalArticlepeer-review

Abstract

Fibrillary glomerulonephritis (GN) is an uncommon cause of rapidly progressive kidney failure. We report a case of rapidly progressive kidney failure with kidney biopsy showing crescentic GN on light microscopy and immunofluorescence showing linear/globular glomerular basement membrane (GBM) staining for immunoglobulin G and C3, consistent with anti-GBM disease. However, electron microscopy showed fibrillary deposits in the GBM, suggesting a diagnosis of fibrillary GN. As exemplified by this case, it is important to consider fibrillary GN in the differential diagnosis of crescentic GN with linear immunoglobulin G deposits within the GBM. Electron microscopy is crucial to make this diagnosis.

Original languageEnglish (US)
Pages (from-to)157-159
Number of pages3
JournalAmerican Journal of Kidney Diseases
Volume60
Issue number1
DOIs
StatePublished - Jul 1 2012

Keywords

  • Fibrillary glomerulonephritis
  • rapidly progressive glomerulonephritis

ASJC Scopus subject areas

  • Nephrology

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