Fiber-optic nonlinear endomicroscopy with focus scanning by using shape memory alloy actuation

Yicong Wu, Yuying Zhang, Jiefeng Xi, Ming Jun Li, Xingde Li

Research output: Contribution to journalArticle

Abstract

A miniature fiber optic endomicroscope with built-in dynamic focus scanning capability is developed for the first time for 3-D two-photon fluorescence (TPF) imaging of biological samples. Fast2-D lateral beam scanning is realized by resonantly vibrating a double-clad fiber cantilever with a tubular piezoactuator. Slow axial scanning is achieved by moving the distal end of the imaging probe with an extremely compact electrically driven shape memory alloy (SMA). The 10-mm-long SMA allows 150-μm contractions with a driving voltage varying only from 50 to 100 mV. The response of the SMA contraction with the applied voltage is nonlinear, but repeatable and can be accurately calibrated. Depth-resolved imaging of acriflavine-stained biological tissues and unstained white paper with the endomicroscope is performed, and the results demonstrate the feasibility of 3-D nonlinear optical imaging with the SMA-based scanning fiber-optic endomicroscope.

Original languageEnglish (US)
Article number060506
JournalJournal of Biomedical Optics
Volume15
Issue number6
DOIs
StatePublished - Nov 2010

Fingerprint

shape memory alloys
Shape memory effect
actuation
Fiber optics
fiber optics
Scanning
Imaging techniques
scanning
contraction
acriflavine
Acriflavine
piezoelectric actuators
Electric potential
electric potential
Photons
Fluorescence
Tissue
fluorescence
fibers
Fibers

Keywords

  • Endomicroscope
  • Focus scanning
  • Shape memory alloy
  • Two-photon fluorescence

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Fiber-optic nonlinear endomicroscopy with focus scanning by using shape memory alloy actuation. / Wu, Yicong; Zhang, Yuying; Xi, Jiefeng; Li, Ming Jun; Li, Xingde.

In: Journal of Biomedical Optics, Vol. 15, No. 6, 060506, 11.2010.

Research output: Contribution to journalArticle

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