Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue

Yicong Wu, Jiefeng Xi, Michael J. Cobb, Xingde Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A flexible fiber-optic endomicroscopy system was developed for nonlinear optical imaging of biological samples. Double-clad fiber and photonic bandgap fiber were employed in the endomicroscope for femtosecond pulse delivery, dispersion compensation, nonlinear optical signals collection and fast beam scanning. Three-dimensional imaging of biological tissues based on second harmonic generation and two-photon excited fluorescence was performed with the endomicroscope. The depth-resolved imaging results strongly suggest the potential of this flexible fiber-optic microscope system for real-time assessment of both epithelial and stromal structures in luminal organs.

Original languageEnglish (US)
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Pages1851-1852
Number of pages2
StatePublished - Dec 1 2008
Externally publishedYes
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Publication series

NameProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

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ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Wu, Y., Xi, J., Cobb, M. J., & Li, X. (2008). Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 (pp. 1851-1852). [4649541] (Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology").