Fiber-enhanced Raman spectroscopy as a tool for an early detection of Alzheimer's disease biomarkers

P. J. Eravuchira, M. Banchelli, C. D'Andrea, M. De Angelis, P. Matteini, Israel Gannot

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Alzheimer's disease (AD) is an irreversible progressive disease that damages the brain cell and affects the cognitive abilities. Hence an early detection of AD biomarkers is vital for the drug treatment. Considering this, we developed a sensitive and reliable sensing tool based on fiber-enhanced Raman spectroscopic technique for the detection of AD biomarkers. The fiber-enhanced Raman measurements were performed using a hollow core photonic crystal fiber, and a comparison of Raman spectra of samples in a conventional cuvette and with the fiber was carried out. The results showed a high enhancement of Raman signal of samples measured with a fiber compared to the measurements carried out in the cuvette.

Original languageEnglish (US)
Title of host publicationOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX
EditorsIsrael Gannot, Israel Gannot
PublisherSPIE
ISBN (Electronic)9781510623866
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes
EventOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX 2019 - San Francisco, United States
Duration: Feb 2 2019Feb 3 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10872
ISSN (Print)1605-7422

Conference

ConferenceOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX 2019
CountryUnited States
CitySan Francisco
Period2/2/192/3/19

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Keywords

  • Alzheimer's disease
  • Fiber-enhanced Raman spectroscopy
  • Hollow core photonic crystal fiber

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Eravuchira, P. J., Banchelli, M., D'Andrea, C., De Angelis, M., Matteini, P., & Gannot, I. (2019). Fiber-enhanced Raman spectroscopy as a tool for an early detection of Alzheimer's disease biomarkers. In I. Gannot, & I. Gannot (Eds.), Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX [1087211] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10872). SPIE. https://doi.org/10.1117/12.2516545