Fewer dopamine transporter receptors in the prefrontal cortex of cocaine users

Ana Hitri, Manuel F. Casanova, Joel E. Kleinman, Richard Jed Wyatt

Research output: Contribution to journalArticlepeer-review

Abstract

The authors investigated dopamine transporter receptor binding in the post-mortem prefrontal cortex of 13 subjects with histories of cocaine use who had positive blood screens for cocaine at autopsy and 13 comparison subjects with no history of cocaine use and negative blood screens for cocaine at autopsy. Synaptosomes from pulverized prefrontal cortex were assayed with [3H]GBR 12935 for dopamine transporter receptor. There was a 38% decrease in number of binding sites but no change in affinity constants in the cocaine users.

Original languageEnglish (US)
Pages (from-to)1074-1076
Number of pages3
JournalAmerican Journal of Psychiatry
Volume151
Issue number7
DOIs
StatePublished - Jul 1994
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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