FEV1 is a better predictor of mortality than FVC: The platino cohort study

Ana Maria B Menezes, Rogelio Pérez-Padilla, Fernando César Wehrmeister, Maria Victorina LopezVarela, Adriana Muiño, Gonzalo Valdivia, Carmen Lisboa, José Roberto B Jardim, Maria Montes De Oca, Carlos Talamo, Renata Bielemann, Mariana Gazzotti, Ruy Laurenti, Bartolomé Celli, Cesar G. Victora

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Results: Main causes of death were cardiovascular, respiratory and cancer. Baseline COPD was associated with overall mortality (HR = 1.43 for FEV1/FVC1/FEV6 1 was risk for overall and respiratory mortality (both genders combined). FVC was not associated with overall mortality. For most COPD criteria sensitivity was low and specificity high. The area under the curve for FEV1 was greater than for FVC for overall and cardiovascular mortality.

Objective: To determine whether the presence of chronic obstructive lung disease (COPD) and reduction of lung function parameters were predictors of mortality in a cohort.

Materials/Patients and Methods: Population based cohorts were followed in Montevideo, Santiago and Sao Paulo during 5, 6 and 9 years, respectively. Outcomes included all-cause, cardiovascular, respiratory and cancer mortality; exposures were COPD, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Cox regression was used for analyses. Sensitivity, specificity, positive and negative predictive values, receiver operator characteristics curves and Youden's index were calculated.

Answer to the Question: COPD and low FEV1 are important predictors for overall and cardiovascular mortality in Latin America. The PLATINO study has been sponsored bv The Asociación Latinoamericana de Tórax (ALAT), Boehrinaer Inaelheim GmbH, GlaxoSmithKline and Novartis for the collection ot the data during the held work. This does not alter the authors adherence to PLOS ONE policies on sharing data and materials. The funders had no role in study desian, data collection and analysis, decision to publish, or preparation of the manuscript.

Original languageEnglish (US)
Article numbere109732
JournalPLoS One
Issue number10
StatePublished - Oct 6 2014
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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