TY - JOUR
T1 - FEV1 is a better predictor of mortality than FVC
T2 - The platino cohort study
AU - Menezes, Ana Maria B
AU - Pérez-Padilla, Rogelio
AU - Wehrmeister, Fernando César
AU - LopezVarela, Maria Victorina
AU - Muiño, Adriana
AU - Valdivia, Gonzalo
AU - Lisboa, Carmen
AU - Jardim, José Roberto B
AU - De Oca, Maria Montes
AU - Talamo, Carlos
AU - Bielemann, Renata
AU - Gazzotti, Mariana
AU - Laurenti, Ruy
AU - Celli, Bartolomé
AU - Victora, Cesar G.
PY - 2014/10/6
Y1 - 2014/10/6
N2 - Results: Main causes of death were cardiovascular, respiratory and cancer. Baseline COPD was associated with overall mortality (HR = 1.43 for FEV1/FVC1/FEV6 1 was risk for overall and respiratory mortality (both genders combined). FVC was not associated with overall mortality. For most COPD criteria sensitivity was low and specificity high. The area under the curve for FEV1 was greater than for FVC for overall and cardiovascular mortality.Objective: To determine whether the presence of chronic obstructive lung disease (COPD) and reduction of lung function parameters were predictors of mortality in a cohort.Materials/Patients and Methods: Population based cohorts were followed in Montevideo, Santiago and Sao Paulo during 5, 6 and 9 years, respectively. Outcomes included all-cause, cardiovascular, respiratory and cancer mortality; exposures were COPD, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Cox regression was used for analyses. Sensitivity, specificity, positive and negative predictive values, receiver operator characteristics curves and Youden's index were calculated.Answer to the Question: COPD and low FEV1 are important predictors for overall and cardiovascular mortality in Latin America. The PLATINO study has been sponsored bv The Asociación Latinoamericana de Tórax (ALAT), Boehrinaer Inaelheim GmbH, GlaxoSmithKline and Novartis for the collection ot the data during the held work. This does not alter the authors adherence to PLOS ONE policies on sharing data and materials. The funders had no role in study desian, data collection and analysis, decision to publish, or preparation of the manuscript.
AB - Results: Main causes of death were cardiovascular, respiratory and cancer. Baseline COPD was associated with overall mortality (HR = 1.43 for FEV1/FVC1/FEV6 1 was risk for overall and respiratory mortality (both genders combined). FVC was not associated with overall mortality. For most COPD criteria sensitivity was low and specificity high. The area under the curve for FEV1 was greater than for FVC for overall and cardiovascular mortality.Objective: To determine whether the presence of chronic obstructive lung disease (COPD) and reduction of lung function parameters were predictors of mortality in a cohort.Materials/Patients and Methods: Population based cohorts were followed in Montevideo, Santiago and Sao Paulo during 5, 6 and 9 years, respectively. Outcomes included all-cause, cardiovascular, respiratory and cancer mortality; exposures were COPD, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Cox regression was used for analyses. Sensitivity, specificity, positive and negative predictive values, receiver operator characteristics curves and Youden's index were calculated.Answer to the Question: COPD and low FEV1 are important predictors for overall and cardiovascular mortality in Latin America. The PLATINO study has been sponsored bv The Asociación Latinoamericana de Tórax (ALAT), Boehrinaer Inaelheim GmbH, GlaxoSmithKline and Novartis for the collection ot the data during the held work. This does not alter the authors adherence to PLOS ONE policies on sharing data and materials. The funders had no role in study desian, data collection and analysis, decision to publish, or preparation of the manuscript.
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U2 - 10.1371/journal.pone.0109732
DO - 10.1371/journal.pone.0109732
M3 - Article
C2 - 25285441
AN - SCOPUS:84907805282
SN - 1932-6203
VL - 9
JO - PLoS One
JF - PLoS One
IS - 10
M1 - e109732
ER -