Fetoscopic tracheal occlusion for treatment of non-isolated congenital diaphragmatic hernia

Research output: Contribution to journalArticle

Abstract

Fetoscopic endotracheal occlusion (FETO) is a prenatal treatment that may increase survival in severe congenital diaphragmatic hernia (CDH). In the USA, FETO is offered for isolated severe left-sided CDH in the context of an FDA-approved feasibility study. FETO in non-isolated cases of severe CDH is only performed with a compassionate use exemption from US regulatory bodies. Anomalies frequently associated with CDH include congenital cystic lesions of the lung and cardiac defects. We describe two cases of non-isolated severe left-sided CDH that underwent prenatal FETO, survived after birth and underwent postnatal surgical repair. The potential benefit of FETO in this setting is discussed.

Original languageEnglish (US)
JournalPrenatal Diagnosis
DOIs
StateAccepted/In press - 2017

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Compassionate Use Trials
Therapeutics
Feasibility Studies
Congenital Diaphragmatic Hernias
Parturition
Lung

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

Cite this

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title = "Fetoscopic tracheal occlusion for treatment of non-isolated congenital diaphragmatic hernia",
abstract = "Fetoscopic endotracheal occlusion (FETO) is a prenatal treatment that may increase survival in severe congenital diaphragmatic hernia (CDH). In the USA, FETO is offered for isolated severe left-sided CDH in the context of an FDA-approved feasibility study. FETO in non-isolated cases of severe CDH is only performed with a compassionate use exemption from US regulatory bodies. Anomalies frequently associated with CDH include congenital cystic lesions of the lung and cardiac defects. We describe two cases of non-isolated severe left-sided CDH that underwent prenatal FETO, survived after birth and underwent postnatal surgical repair. The potential benefit of FETO in this setting is discussed.",
author = "Viola Seravalli and Eric Jelin and Jena Miller and Aylin Tekes and Luca Vricella and Ahmet Baschat",
year = "2017",
doi = "10.1002/pd.5139",
language = "English (US)",
journal = "Prenatal Diagnosis",
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T1 - Fetoscopic tracheal occlusion for treatment of non-isolated congenital diaphragmatic hernia

AU - Seravalli, Viola

AU - Jelin, Eric

AU - Miller, Jena

AU - Tekes, Aylin

AU - Vricella, Luca

AU - Baschat, Ahmet

PY - 2017

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N2 - Fetoscopic endotracheal occlusion (FETO) is a prenatal treatment that may increase survival in severe congenital diaphragmatic hernia (CDH). In the USA, FETO is offered for isolated severe left-sided CDH in the context of an FDA-approved feasibility study. FETO in non-isolated cases of severe CDH is only performed with a compassionate use exemption from US regulatory bodies. Anomalies frequently associated with CDH include congenital cystic lesions of the lung and cardiac defects. We describe two cases of non-isolated severe left-sided CDH that underwent prenatal FETO, survived after birth and underwent postnatal surgical repair. The potential benefit of FETO in this setting is discussed.

AB - Fetoscopic endotracheal occlusion (FETO) is a prenatal treatment that may increase survival in severe congenital diaphragmatic hernia (CDH). In the USA, FETO is offered for isolated severe left-sided CDH in the context of an FDA-approved feasibility study. FETO in non-isolated cases of severe CDH is only performed with a compassionate use exemption from US regulatory bodies. Anomalies frequently associated with CDH include congenital cystic lesions of the lung and cardiac defects. We describe two cases of non-isolated severe left-sided CDH that underwent prenatal FETO, survived after birth and underwent postnatal surgical repair. The potential benefit of FETO in this setting is discussed.

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