TY - JOUR
T1 - Fetal outcome of lupus pregnancy
T2 - A retrospective case-control study of the Hopkins Lupus Cohort
AU - Petri, M.
AU - Allbritton, Jill Irene
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1993
Y1 - 1993
N2 - Objective. To determine the frequency of pregnancy loss, preterm birth, and therapeutic abortion in patients with systemic lupus erythematosus (SLE) versus controls. Method. The outcome of lupus pregnancy was determined in the largest retrospective case-control study to date, involving 203 patients with SLE with 481 pregnancies, 166 'best friends' with 356 pregnancies and 177 relatives with 566 pregnancies. Results. Pregnancy loss (spontaneous abortion, miscarriage, or stillbirth) was more common in lupus pregnancies (21%) than in pregnancies in friends (14%, p = 0.01) or in relatives (8%, p ≤ 0.0001) and was more common after the diagnosis of SLE than before (27 vs 19%, p = 0.04). Preterm birth (≤ 36 weeks) was more common in lupus pregnancies (12%) than in pregnancies in friends (4%, p ≤ 0.0001) or in relatives (4% , p ≤ 0.0001) and was more common after the diagnosis of SLE than before (24 vs 6%, p ≤ 0.0001). Preterm birth in lupus pregnancies after the diagnosis of SLE was associated with nonhigh school graduates (p = 0.001), Raynaud's phenomenon (p = 0.007), and hypertension requiring treatment (p = 0.01). Conclusion. We conclude that both pregnancy loss and preterm birth are significantly increased in lupus pregnancy versus control pregnancy and that these pregnancy outcomes are more common after the diagnosis of SLE.
AB - Objective. To determine the frequency of pregnancy loss, preterm birth, and therapeutic abortion in patients with systemic lupus erythematosus (SLE) versus controls. Method. The outcome of lupus pregnancy was determined in the largest retrospective case-control study to date, involving 203 patients with SLE with 481 pregnancies, 166 'best friends' with 356 pregnancies and 177 relatives with 566 pregnancies. Results. Pregnancy loss (spontaneous abortion, miscarriage, or stillbirth) was more common in lupus pregnancies (21%) than in pregnancies in friends (14%, p = 0.01) or in relatives (8%, p ≤ 0.0001) and was more common after the diagnosis of SLE than before (27 vs 19%, p = 0.04). Preterm birth (≤ 36 weeks) was more common in lupus pregnancies (12%) than in pregnancies in friends (4%, p ≤ 0.0001) or in relatives (4% , p ≤ 0.0001) and was more common after the diagnosis of SLE than before (24 vs 6%, p ≤ 0.0001). Preterm birth in lupus pregnancies after the diagnosis of SLE was associated with nonhigh school graduates (p = 0.001), Raynaud's phenomenon (p = 0.007), and hypertension requiring treatment (p = 0.01). Conclusion. We conclude that both pregnancy loss and preterm birth are significantly increased in lupus pregnancy versus control pregnancy and that these pregnancy outcomes are more common after the diagnosis of SLE.
KW - lupus pregnancy
KW - systemic lupus erythematosus
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M3 - Article
C2 - 8496859
AN - SCOPUS:0027263663
SN - 0315-162X
VL - 20
SP - 650
EP - 656
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 4
ER -