Abstract
Telencephalic hypoplasia induced by methylazoxymethanol acetate (MAM) resulted in increased activity of tyrosine hydroxylase in the striatum, indicative of a relative increase in the density of dopaminergic terminals in the remaining tissue. Administration of the dopamine receptor stimulant, apomorphine, or the receptor blocker, haloperidol, produced less stereotypy and catalepsy, respectively, in rats lesioned with methylazoxymethanol, compared to controls. These behavioral changes probably resulted from the loss of striatal perikarya and consequent decrease in nigrostriatal dopaminergic target sites caused by methylazoxymethanol.
Original language | English (US) |
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Pages (from-to) | 1057-1062 |
Number of pages | 6 |
Journal | Neuropharmacology |
Volume | 24 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1985 |
Externally published | Yes |
Keywords
- apomorphine
- catalepsy
- haloperidol
- methylazoxymethanol
- stereotypy
ASJC Scopus subject areas
- Pharmacology
- Cellular and Molecular Neuroscience