Fetal magnetic resonance imaging in midline malformations of the central nervous system and review of the literature

P. Dill, A. Poretti, E. Boltshauser, T. A.G.M. Huisman

Research output: Contribution to journalArticlepeer-review

Abstract

Fetal magnetic resonance imaging (MRI) is a well-established second line imaging modality in identifying complex pathologies of the central nervous system (CNS), especially when ultrasound (US) findings are equivocal. It may enable an early and precise diagnosis, which is essential in terms of management of pregnancy and pre-, peri- and postnatal care. We present three cases with rare complex midline malformations of the CNS, diagnosed prenatally by fetal MRI. Two cases revealed holoprosencephaly; one case demonstrated rhombencephalosynapsis. In addition, we reviewed the literature and provide a summary of recent findings regarding cerebral midline development and discuss the advantages of fetal MRI.

Original languageEnglish (US)
Pages (from-to)138-146
Number of pages9
JournalJournal of Neuroradiology
Volume36
Issue number3
DOIs
StatePublished - Jun 2009

Keywords

  • Cerebral midline malformation
  • Fetal magnetic resonance imaging
  • Gomez-Lopez-Hernandez Syndrome
  • Holoprosencephaly
  • Rhombencephalosynapsis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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