Fetal human neural progenitors can be the target for tumor transformation

Yajun Wang, Yun Bai, Xiaoxia Li, Qikuan Hu, Changsheng Lin, Zhifeng Xiao, Yinan Liu, Jinchong Xu, Li Shen, Linsong Li

Research output: Contribution to journalArticle

Abstract

The hypothesis that stem cells may seed cancer has emerged from the cancer stem cells concept. However, the experimental systems necessary to provide more direct evidence to support the hypothesis have been lacking. We have used fetal neural progenitor cells (hNPC) transduced with the telomerase hTERT gene to investigate the neoplastic potential of hNPCs. The hTERT-transduced line, hNPCs-G3 lost normal diploid karyotype, showed loss of contact inhibition, anchorage independence, and formed neuroblastoma-like tumours in all of 10 mice.These data suggest that hNPCs have the potential for neoplastic transformation.These data have implications for providing a novel tool to test the feasibility of new anti-cancer treatment strategies and raise the possibility of a risk for the use of hNPCs in cell transplantation.

Original languageEnglish (US)
Pages (from-to)1907-1912
Number of pages6
JournalNeuroreport
Volume15
Issue number12
DOIs
StatePublished - Aug 26 2004
Externally publishedYes

Keywords

  • Mutation
  • Neoplasia
  • Transformation
  • hNPCs
  • hTERT

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Wang, Y., Bai, Y., Li, X., Hu, Q., Lin, C., Xiao, Z., Liu, Y., Xu, J., Shen, L., & Li, L. (2004). Fetal human neural progenitors can be the target for tumor transformation. Neuroreport, 15(12), 1907-1912. https://doi.org/10.1097/00001756-200408260-00015