Fetal hepatic haematopoiesis is modulated by arterial blood flow to the liver

Shaun M. Kunisaki, Humberto Azpurua, Julie R. Fuchs, Sara C. Graves, David Zurakowski, Dario O. Fauza

Research output: Contribution to journalArticlepeer-review

Abstract

We describe an as yet unrecognised relationship between fetal hepatic haematopoiesis and arterial blood flow to the liver. To increase hepatic arterial flow, the common bile duct (CBD) was ligated in fetal lambs. Reduction of hepatic arterial flow was accomplished in age-matched animals by hepatic artery (HA) ligation. Multiple analyses performed before term showed a significant increase in haematopoietic cell density in CBD animals when compared with sham controls and HA animals. In contrast, HA animals demonstrated a decrease in liver haematopoietic activity. Fetal hepatic haematopoiesis is dependent upon arterial blood flow to the liver.

Original languageEnglish (US)
Pages (from-to)330-332
Number of pages3
JournalBritish journal of haematology
Volume134
Issue number3
DOIs
StatePublished - Aug 2006
Externally publishedYes

Keywords

  • Fetal haematopoiesis
  • Fetus
  • Haematopoiesis
  • Hepatic artery
  • Hepatic haematopoiesis

ASJC Scopus subject areas

  • Hematology

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