Abstract
We describe an as yet unrecognised relationship between fetal hepatic haematopoiesis and arterial blood flow to the liver. To increase hepatic arterial flow, the common bile duct (CBD) was ligated in fetal lambs. Reduction of hepatic arterial flow was accomplished in age-matched animals by hepatic artery (HA) ligation. Multiple analyses performed before term showed a significant increase in haematopoietic cell density in CBD animals when compared with sham controls and HA animals. In contrast, HA animals demonstrated a decrease in liver haematopoietic activity. Fetal hepatic haematopoiesis is dependent upon arterial blood flow to the liver.
Original language | English (US) |
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Pages (from-to) | 330-332 |
Number of pages | 3 |
Journal | British journal of haematology |
Volume | 134 |
Issue number | 3 |
DOIs | |
State | Published - Aug 2006 |
Externally published | Yes |
Keywords
- Fetal haematopoiesis
- Fetus
- Haematopoiesis
- Hepatic artery
- Hepatic haematopoiesis
ASJC Scopus subject areas
- Hematology