'Fetal' erythrocytes are present in older children and certain adults with hematologic disorders. To determine if regenerating bone marrow produces such cells, the blood of 7 allogeneic bone marrow transplant recipients was examined. Six patients were engrafted with donor cells, while one patient recovered autologous bone marrow after rejection of a marrow transplant. All 7 patients had fetal hemoglobin levels of up to 10% by 100 days after transplantation. In 3 patients, the Gγ to Aγ ratio in the fetal hemoglobin was 'newborn', while in one it was 'adult'. Gamma chain synthesis in blood and bone marrow never exceeded 20% of total non alpha globin synthesis. The fetal hemoglobin was heterogeneously distributed in the cells. High titer i antigen also appeared. All fetal characteristics declined by 200 days. Erythropoiesis during bone marrow recovery appears to be associated with an accelerated, albeit partial, recapitulation of ontogeny.
|Original language||English (US)|
|Number of pages||11|
|State||Published - 1976|
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