Fetal CHD and perinatal outcomes

Christina J. Ge; Amanda C. Mahle; Irina Burd; Priya Sekar; Eric B. Jelin

doi:10.1017/S1047951120000785

Fetal CHD and perinatal outcomes

Christina J. Ge, Amanda C. Mahle, Irina Burd, Priya Sekar, Eric B. Jelin

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD.Study design: A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes included the incidence of preterm delivery and mode of delivery.Results: Gestational age at delivery was significantly lower between the CHD and non-anomalous cohorts (38.6 and 39.1 weeks, respectively). Neonates with CHD had a significantly lower birth weights (p < 0.001). There was an approximately 1.5-fold increase in the rate of primary cesarean sections associated with prenatally diagnosed CHD with an odds ratio of 1.49 (95% CI 1.06-2.10).Conclusions: Our study provides additional evidence that the prenatal diagnosis of CHD is associated with a lower birth weight, preterm delivery, and with an increased risk of delivery by primary cesarean section.

Original language	English (US)
Pages (from-to)	686-691
Number of pages	6
Journal	Cardiology in the young
Volume	30
Issue number	5
DOIs	https://doi.org/10.1017/S1047951120000785
State	Published - May 1 2020

Keywords

CHD
fetal anomalies
prenatal
preterm delivery
ultrasound

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

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10.1017/S1047951120000785

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title = "Fetal CHD and perinatal outcomes",

abstract = "Objective: To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD.Study design: A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes included the incidence of preterm delivery and mode of delivery.Results: Gestational age at delivery was significantly lower between the CHD and non-anomalous cohorts (38.6 and 39.1 weeks, respectively). Neonates with CHD had a significantly lower birth weights (p < 0.001). There was an approximately 1.5-fold increase in the rate of primary cesarean sections associated with prenatally diagnosed CHD with an odds ratio of 1.49 (95% CI 1.06-2.10).Conclusions: Our study provides additional evidence that the prenatal diagnosis of CHD is associated with a lower birth weight, preterm delivery, and with an increased risk of delivery by primary cesarean section.",

keywords = "CHD, fetal anomalies, prenatal, preterm delivery, ultrasound",

author = "Ge, {Christina J.} and Mahle, {Amanda C.} and Irina Burd and Priya Sekar and Jelin, {Eric B.}",

note = "Funding Information: Angie Jelin is funded by a Johns Hopkins Women{\textquoteright}s Health Scholarship. Grant IO# 90072576 was funded by the Saudi Arabian Cultural Mission for support of a research fellow. Funding Information: Angie Jelin is funded by a Johns Hopkins Women's Health Scholarship. Grant IO# 90072576 was funded by the Saudi Arabian Cultural Mission for support of a research fellow. Publisher Copyright: {\textcopyright} The Author(s) 2020. Published by Cambridge University Press.",

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doi = "10.1017/S1047951120000785",

language = "English (US)",

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AU - Ge, Christina J.

AU - Mahle, Amanda C.

AU - Burd, Irina

AU - Sekar, Priya

AU - Jelin, Eric B.

N1 - Funding Information: Angie Jelin is funded by a Johns Hopkins Women’s Health Scholarship. Grant IO# 90072576 was funded by the Saudi Arabian Cultural Mission for support of a research fellow. Funding Information: Angie Jelin is funded by a Johns Hopkins Women's Health Scholarship. Grant IO# 90072576 was funded by the Saudi Arabian Cultural Mission for support of a research fellow. Publisher Copyright: © The Author(s) 2020. Published by Cambridge University Press.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Objective: To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD.Study design: A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes included the incidence of preterm delivery and mode of delivery.Results: Gestational age at delivery was significantly lower between the CHD and non-anomalous cohorts (38.6 and 39.1 weeks, respectively). Neonates with CHD had a significantly lower birth weights (p < 0.001). There was an approximately 1.5-fold increase in the rate of primary cesarean sections associated with prenatally diagnosed CHD with an odds ratio of 1.49 (95% CI 1.06-2.10).Conclusions: Our study provides additional evidence that the prenatal diagnosis of CHD is associated with a lower birth weight, preterm delivery, and with an increased risk of delivery by primary cesarean section.

AB - Objective: To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD.Study design: A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes included the incidence of preterm delivery and mode of delivery.Results: Gestational age at delivery was significantly lower between the CHD and non-anomalous cohorts (38.6 and 39.1 weeks, respectively). Neonates with CHD had a significantly lower birth weights (p < 0.001). There was an approximately 1.5-fold increase in the rate of primary cesarean sections associated with prenatally diagnosed CHD with an odds ratio of 1.49 (95% CI 1.06-2.10).Conclusions: Our study provides additional evidence that the prenatal diagnosis of CHD is associated with a lower birth weight, preterm delivery, and with an increased risk of delivery by primary cesarean section.

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Fetal CHD and perinatal outcomes

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Keywords

ASJC Scopus subject areas

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