Fertility pattern does not explain social gradient in breast cancer in Denmark

Hella Danø, Kasper Daniel Hansen, Per Jensen, Jørgen Holm Petersen, Rune Jacobsen, Marianne Ewertz, Elsebeth Lynge

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was undertaken to assess the impact of reproductive behavior on the social class gradient in breast cancer occurrence in Denmark. Objectives were to study whether the gradient across socioeconomic groups could be explained by fertility differences, whether the gradient across educational groups could be explained by fertility differences and whether the effect of socioeconomic group on breast cancer incidence and mortality could be explained by education and vice versa. We studied 674,084 women aged 20-39 at the census on 9 November 1970 for whom we had complete data on fertility history. The cohort was followed up for breast cancer incidence and mortality until 8 November 1998. Fertility history varied considerably across socioeconomic group, where 38% of the academics were childless at the age of 30, in contrast to only 8% of women in agriculture. The academics had the highest risk of breast cancer and women in agriculture had the lowest risk. For incidence, the gradient in the relative risks was 1.74, which changed to 1.49 when fertility history was incorporated and to 1.29 when school education was also taken into account. For school education, women with ≥ 12 years of schooling had the highest risk and women with ≤ 7 years of schooling had the lowest risk. For incidence, the gradient in the relative risk was 1.38, which changed to 1.26 when fertility history was incorporated and to 1.22 when socioeconomic group was also taken into account.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalInternational Journal of Cancer
Volume111
Issue number3
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

Keywords

  • Breast cancer
  • Education
  • Fertility
  • Occupation
  • Registers
  • Socioeconomic status

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Fertility pattern does not explain social gradient in breast cancer in Denmark'. Together they form a unique fingerprint.

Cite this