TY - JOUR
T1 - Fertilisation involving ageing gametes, major birth defects, and Down's syndrome
AU - Simpson, Joe Leigh
AU - Gray, Ron
AU - Perez, Alfredo
AU - Mena, Patricio
AU - Queenan, John T.
AU - Barbato, Michele
AU - Pardo, Francesco
AU - Kambic, Robert
AU - Jennings, Victoria
N1 - Funding Information:
Funding was provided by the US Agency for International Development (USAID), through a contract awarded to Georgetown University (Institute for Reproductive Health). Travel funds but no honorariums were provided to authors. Funding agencies had no influence over the conduct of the study, the writing of the report, or the decision to publish.
PY - 2002/5/11
Y1 - 2002/5/11
N2 - For many years, ageing of gametes as a result of prolonged retention in the female reproductive tract before fertilisation has been circumstantially associated with major birth defects. To assess this association, we studied pregnant women who had recorded the timing, with regard to presumed ovulation, of the coital event leading to conception. We found major anomalies in 11 (2.7%) of 400 infants born to women with optimally timed conceptions (on the day of or 1 day before ovulation), compared with 14 (2.5%) of 538 infants of women with non-optimally timed conceptions (odds ratio 0.94, 95% CI 0.43-2.06). The numbers of infants with Down's syndrome were two (0.5%) of 400, and four (0.7%) of 538, respectively (1.48, 0.27-8.06). There is no association between ageing gametes and major birth defects, including Down's syndrome.
AB - For many years, ageing of gametes as a result of prolonged retention in the female reproductive tract before fertilisation has been circumstantially associated with major birth defects. To assess this association, we studied pregnant women who had recorded the timing, with regard to presumed ovulation, of the coital event leading to conception. We found major anomalies in 11 (2.7%) of 400 infants born to women with optimally timed conceptions (on the day of or 1 day before ovulation), compared with 14 (2.5%) of 538 infants of women with non-optimally timed conceptions (odds ratio 0.94, 95% CI 0.43-2.06). The numbers of infants with Down's syndrome were two (0.5%) of 400, and four (0.7%) of 538, respectively (1.48, 0.27-8.06). There is no association between ageing gametes and major birth defects, including Down's syndrome.
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U2 - 10.1016/S0140-6736(02)08559-8
DO - 10.1016/S0140-6736(02)08559-8
M3 - Article
C2 - 12020531
AN - SCOPUS:0037062232
VL - 359
SP - 1670
EP - 1671
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 9318
ER -