Ferroptosis in nervous system diseases

Jieru Wan; Xiuli Yang; Jian Wang

doi:10.1007/978-3-030-26780-3_10

Ferroptosis in nervous system diseases

Jieru Wan, Xiuli Yang, Jian Wang

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Ferroptosis is a non-apoptotic form of regulated cell death characterized by iron-dependent accumulation of lethal lipid peroxidation. First identified in cancer cells in 2012, ferroptosis has significant implications in several nervous system disorders. Studies have revealed the presence of iron accumulation, lipid peroxidation, glutathione reduction, and glutathione peroxidase 4 inhibition in various brain diseases, and ferroptotic inhibitors have been shown to protect neurons and improve cognitive function in experimental cellular and/or animal models. In this chapter, we describe the role that ferroptotic mechanisms play in different brain diseases and discuss how this knowledge can be harnessed to prevent and treat nervous system diseases.

Original language	English (US)
Title of host publication	Ferroptosis in Health and Disease
Publisher	Springer International Publishing
Pages	173-195
Number of pages	23
ISBN (Electronic)	9783030267803
ISBN (Print)	9783030267797
DOIs	https://doi.org/10.1007/978-3-030-26780-3_10
State	Published - Oct 10 2019

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Medicine

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10.1007/978-3-030-26780-3_10

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abstract = "Ferroptosis is a non-apoptotic form of regulated cell death characterized by iron-dependent accumulation of lethal lipid peroxidation. First identified in cancer cells in 2012, ferroptosis has significant implications in several nervous system disorders. Studies have revealed the presence of iron accumulation, lipid peroxidation, glutathione reduction, and glutathione peroxidase 4 inhibition in various brain diseases, and ferroptotic inhibitors have been shown to protect neurons and improve cognitive function in experimental cellular and/or animal models. In this chapter, we describe the role that ferroptotic mechanisms play in different brain diseases and discuss how this knowledge can be harnessed to prevent and treat nervous system diseases.",

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Ferroptosis in nervous system diseases

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