Ferrite-enhanced MR imaging of hepatic lymphoma: An experimental study in rats

R. Weissleder, D. D. Stark, C. C. Compton, J. Wittenberg, J. T. Ferrucci

Research output: Contribution to journalArticle

Abstract

The purpose of this investigation was to define the potential of unenhanced and ferrite-enhanced MR to detect hepatic lymphoma. Rats were implanted with diffuse and focal hepatic lymphoma. Both in vitro measurements of relaxation times and in vivo MR imaging of normal liver and of diffuse and focal hepatic lymphoma were compared. Diffuse infiltrative hepatic lymphoma showed increased T1 (45%) and T2 (41%) relaxation times in vitro, but could not be distinguished from normal control livers on in vivo spin echo (SE) images with a repetition time of 500 msec and an echo time of 30 msec (SE 500/30) or SE 1500/60 images. Focal hepatic lymphoma showed increased T1 (185%) and T2 (115%) relaxation times relative to normal liver tissue. Focal hepatic lymphoma was undetectable on unenhanced SE 500/30 MR images (contrast-to-noise ratio, C/N = 0.4) and was slightly hyperintense on SE 1500/60 images (C/N = 1.1). Ferrite (50 μmol Fe/kg) was administered to improve tissue contrast. In normal control animals, T2 of liver in vitro decreased from 29.3 ± 3.3 msec to 11.1 ± 1.2 msec, and image signal-to-noise ratio (S/N) of liver in vivo decreased from 16.1 ± 2.4 to 2.8 ± 0.3 (p

Original languageEnglish (US)
Pages (from-to)1161-1165
Number of pages5
JournalAmerican Journal of Roentgenology
Volume149
Issue number6
StatePublished - 1987
Externally publishedYes

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Lymphoma
Liver
ferrite
Signal-To-Noise Ratio
Noise

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Weissleder, R., Stark, D. D., Compton, C. C., Wittenberg, J., & Ferrucci, J. T. (1987). Ferrite-enhanced MR imaging of hepatic lymphoma: An experimental study in rats. American Journal of Roentgenology, 149(6), 1161-1165.

Ferrite-enhanced MR imaging of hepatic lymphoma : An experimental study in rats. / Weissleder, R.; Stark, D. D.; Compton, C. C.; Wittenberg, J.; Ferrucci, J. T.

In: American Journal of Roentgenology, Vol. 149, No. 6, 1987, p. 1161-1165.

Research output: Contribution to journalArticle

Weissleder, R, Stark, DD, Compton, CC, Wittenberg, J & Ferrucci, JT 1987, 'Ferrite-enhanced MR imaging of hepatic lymphoma: An experimental study in rats', American Journal of Roentgenology, vol. 149, no. 6, pp. 1161-1165.
Weissleder R, Stark DD, Compton CC, Wittenberg J, Ferrucci JT. Ferrite-enhanced MR imaging of hepatic lymphoma: An experimental study in rats. American Journal of Roentgenology. 1987;149(6):1161-1165.
Weissleder, R. ; Stark, D. D. ; Compton, C. C. ; Wittenberg, J. ; Ferrucci, J. T. / Ferrite-enhanced MR imaging of hepatic lymphoma : An experimental study in rats. In: American Journal of Roentgenology. 1987 ; Vol. 149, No. 6. pp. 1161-1165.
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