Femoral head perfusion and composition

MR imaging and spectroscopic evaluation of patients with systemic lupus erythematosus and at risk for avascular necrosis

David A. Bluemke, Michelle Petri, Elias Zerhouni

Research output: Contribution to journalArticle

Abstract

PURPOSE: To measure fat content and relative marrow perfusion of the femoral head in patients at risk for avascular necrosis. MATERIALS AND METHODS: Thirteen patients with systemic lupus erythematosus (SLE) without avascular necrosis and with long-term corticosteroid treatment and 12 healthy subjects were evaluated. Hip perfusion was assessed with gadolinium-enhanced T1-weighted magnetic resonance (MR) imaging. Marrow composition in the femoral head and neck was measured with hydrogen-1 MR spectroscopy. RESULTS: Percentage fat content in the femoral head was similar between the two groups (SLE patients, 77% ± 5 [standard deviation]; healthy subjects, 78% ± 6; P = .74). Rate of enhancement of the femoral head was significantly higher in the SLE than the healthy group (11%/min ± 6 vs 6.9%/min ± 3, respectively; P = .05), was inversely related to fat content in healthy subjects (r = -.74, P = .02), and was more variable in the SLE group (r = -.53, P = .11). CONCLUSION: Perfusion of the femoral head is inversely related to marrow fat content in healthy subjects and is higher in SLE patients without hip avascular necrosis.

Original languageEnglish (US)
Pages (from-to)433-438
Number of pages6
JournalRadiology
Volume197
Issue number2
StatePublished - Nov 1995

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Magnetic Resonance Angiography
Thigh
Systemic Lupus Erythematosus
Necrosis
Healthy Volunteers
Fats
Perfusion
Bone Marrow
Hip
Femur Neck
Gadolinium
Hydrogen
Adrenal Cortex Hormones
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging

Keywords

  • Bone marrow, MR
  • Hip, MR
  • Hip, necrosis
  • Lupus erythematosus
  • Magnetic resonance (MR), perfusion study
  • Magnetic resonance (MR), spectroscopy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

@article{186cc89e9a704101a70ec8dfd52474d4,
title = "Femoral head perfusion and composition: MR imaging and spectroscopic evaluation of patients with systemic lupus erythematosus and at risk for avascular necrosis",
abstract = "PURPOSE: To measure fat content and relative marrow perfusion of the femoral head in patients at risk for avascular necrosis. MATERIALS AND METHODS: Thirteen patients with systemic lupus erythematosus (SLE) without avascular necrosis and with long-term corticosteroid treatment and 12 healthy subjects were evaluated. Hip perfusion was assessed with gadolinium-enhanced T1-weighted magnetic resonance (MR) imaging. Marrow composition in the femoral head and neck was measured with hydrogen-1 MR spectroscopy. RESULTS: Percentage fat content in the femoral head was similar between the two groups (SLE patients, 77{\%} ± 5 [standard deviation]; healthy subjects, 78{\%} ± 6; P = .74). Rate of enhancement of the femoral head was significantly higher in the SLE than the healthy group (11{\%}/min ± 6 vs 6.9{\%}/min ± 3, respectively; P = .05), was inversely related to fat content in healthy subjects (r = -.74, P = .02), and was more variable in the SLE group (r = -.53, P = .11). CONCLUSION: Perfusion of the femoral head is inversely related to marrow fat content in healthy subjects and is higher in SLE patients without hip avascular necrosis.",
keywords = "Bone marrow, MR, Hip, MR, Hip, necrosis, Lupus erythematosus, Magnetic resonance (MR), perfusion study, Magnetic resonance (MR), spectroscopy",
author = "Bluemke, {David A.} and Michelle Petri and Elias Zerhouni",
year = "1995",
month = "11",
language = "English (US)",
volume = "197",
pages = "433--438",
journal = "Radiology",
issn = "0033-8419",
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TY - JOUR

T1 - Femoral head perfusion and composition

T2 - MR imaging and spectroscopic evaluation of patients with systemic lupus erythematosus and at risk for avascular necrosis

AU - Bluemke, David A.

AU - Petri, Michelle

AU - Zerhouni, Elias

PY - 1995/11

Y1 - 1995/11

N2 - PURPOSE: To measure fat content and relative marrow perfusion of the femoral head in patients at risk for avascular necrosis. MATERIALS AND METHODS: Thirteen patients with systemic lupus erythematosus (SLE) without avascular necrosis and with long-term corticosteroid treatment and 12 healthy subjects were evaluated. Hip perfusion was assessed with gadolinium-enhanced T1-weighted magnetic resonance (MR) imaging. Marrow composition in the femoral head and neck was measured with hydrogen-1 MR spectroscopy. RESULTS: Percentage fat content in the femoral head was similar between the two groups (SLE patients, 77% ± 5 [standard deviation]; healthy subjects, 78% ± 6; P = .74). Rate of enhancement of the femoral head was significantly higher in the SLE than the healthy group (11%/min ± 6 vs 6.9%/min ± 3, respectively; P = .05), was inversely related to fat content in healthy subjects (r = -.74, P = .02), and was more variable in the SLE group (r = -.53, P = .11). CONCLUSION: Perfusion of the femoral head is inversely related to marrow fat content in healthy subjects and is higher in SLE patients without hip avascular necrosis.

AB - PURPOSE: To measure fat content and relative marrow perfusion of the femoral head in patients at risk for avascular necrosis. MATERIALS AND METHODS: Thirteen patients with systemic lupus erythematosus (SLE) without avascular necrosis and with long-term corticosteroid treatment and 12 healthy subjects were evaluated. Hip perfusion was assessed with gadolinium-enhanced T1-weighted magnetic resonance (MR) imaging. Marrow composition in the femoral head and neck was measured with hydrogen-1 MR spectroscopy. RESULTS: Percentage fat content in the femoral head was similar between the two groups (SLE patients, 77% ± 5 [standard deviation]; healthy subjects, 78% ± 6; P = .74). Rate of enhancement of the femoral head was significantly higher in the SLE than the healthy group (11%/min ± 6 vs 6.9%/min ± 3, respectively; P = .05), was inversely related to fat content in healthy subjects (r = -.74, P = .02), and was more variable in the SLE group (r = -.53, P = .11). CONCLUSION: Perfusion of the femoral head is inversely related to marrow fat content in healthy subjects and is higher in SLE patients without hip avascular necrosis.

KW - Bone marrow, MR

KW - Hip, MR

KW - Hip, necrosis

KW - Lupus erythematosus

KW - Magnetic resonance (MR), perfusion study

KW - Magnetic resonance (MR), spectroscopy

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