Femoral Head Blood Flow in Long-Term Steroid Therapy

Study of Rabbit Model

Gwo Jaw Wang, Sandra L. Hubbard, Steven I. Reger, Edward Miller, Warren G. Stamp

Research output: Contribution to journalArticle

Abstract

Using a rabbit model, previous studies showed steroid-induced hyperlipidemia with subsequent fatty embolization of the subchondral arteries and hypertrophy of the marrow fat cells, followed by elevation of femoral head pressure from the normal level of 25 cm to nearly 60 cm H20 after eight weeks of treatment. This has led us to believe that pressure changes lead to decreased blood flow in the femoral head. In our study of 22 New Zealand white adult rabbits, weighing an average of 4.0 kg, 14 received a weekly dose of 12.45 mg of methylprednisolone (Depo-Medrol), and eight served as control. Femoral head blood flow was established using the radioactive microsphere technique. Control and cortisone-treated rabbits had femoral head blood flow measured 6, 8 and 10 weeks after treatment. The average blood flow in the control femoral, heads averaged 0.20S9 ± 0.076 ml/min/gm, with no difference in the left side and the right side. In the treated group, the average blood flow at ten weeks was 0.162 ± 0.039 ml/min/gm on the right and 0.164 ± 0.037 ml/min/gm on the left, which was significantly different. This is parallel to unpredictable clinical findings in human beings.

Original languageEnglish (US)
Pages (from-to)1530-1532
Number of pages3
JournalSouthern Medical Journal
Volume76
Issue number12
StatePublished - 1983
Externally publishedYes

Fingerprint

Thigh
Steroids
Rabbits
Therapeutics
Pressure
Cortisone
Methylprednisolone
Blood Group Antigens
Hyperlipidemias
Microspheres
Adipocytes
Hypertrophy
Arteries
Bone Marrow
Head

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wang, G. J., Hubbard, S. L., Reger, S. I., Miller, E., & Stamp, W. G. (1983). Femoral Head Blood Flow in Long-Term Steroid Therapy: Study of Rabbit Model. Southern Medical Journal, 76(12), 1530-1532.

Femoral Head Blood Flow in Long-Term Steroid Therapy : Study of Rabbit Model. / Wang, Gwo Jaw; Hubbard, Sandra L.; Reger, Steven I.; Miller, Edward; Stamp, Warren G.

In: Southern Medical Journal, Vol. 76, No. 12, 1983, p. 1530-1532.

Research output: Contribution to journalArticle

Wang, GJ, Hubbard, SL, Reger, SI, Miller, E & Stamp, WG 1983, 'Femoral Head Blood Flow in Long-Term Steroid Therapy: Study of Rabbit Model', Southern Medical Journal, vol. 76, no. 12, pp. 1530-1532.
Wang, Gwo Jaw ; Hubbard, Sandra L. ; Reger, Steven I. ; Miller, Edward ; Stamp, Warren G. / Femoral Head Blood Flow in Long-Term Steroid Therapy : Study of Rabbit Model. In: Southern Medical Journal. 1983 ; Vol. 76, No. 12. pp. 1530-1532.
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