Feline penile erection induced by transurethral administration of sodium nitroprusside

Trinity J. Bivalacqua, Hunter C. Champion, Run Wang, Philip J. Kadowitz, Paul C. Doherty, Wayne J.G. Hellstrom

Research output: Contribution to journalArticlepeer-review

Abstract

Nitric oxide (NO) is an important mediator in the relaxation of cavernosal smooth muscle. The aim of this study was to investigate the in vivo feline erectile response after transurethral administration of sodium nitroprusside (SNP), a NO donor drug. Erectile responses after administration of transurethral SNP were compared with those elicited by an intracavernosal control triple-drug combination (1.65 mg papaverine, 25 μg phentolamine, and 0.5 μg prostaglandin E1). SNP was administered via a 20-gauge Jelco intravenous catheter in a volume of 200 μl and changes in intracavernosal pressure, penile length, and systemic blood pressure were monitored. The control triple-drug combination was administered via a 30-gauge needle at the end of each experiment to serve as a control reference. Transurethral administration of SNP (1-4 mg) induced penile erection in a dose-dependent manner with minimal changes in systemic blood pressure. The maximum increase in intracavernosal pressure and penile length after transurethral administration of SNP (4 mg) was significantly less than after the intracavernosal injection of the control triple-drug combination (P < 0.01). These data suggest that transurethral administration of SNP can induce an erectile response in cats with minimal side effects.

Original languageEnglish (US)
Pages (from-to)432-436
Number of pages5
JournalUrological Research
Volume27
Issue number6
DOIs
StatePublished - Dec 1999
Externally publishedYes

Keywords

  • Erectile dysfunction
  • Nitric oxide
  • Penile erection
  • SNP
  • Transurethral
  • cGMP

ASJC Scopus subject areas

  • Urology

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