Feline Papillomas and Papillomaviruses

J. P. Sundberg, M. Van Ranst, R. Montali, B. L. Homer, W. H. Miller, P. H. Rowland, D. W. Scott, J. J. England, R. W. Dunstan, I. Mikaelian, A. B. Jenson

Research output: Contribution to journalArticle

Abstract

Papillomaviruses (PVs) are highly species- and site-specific pathogens of stratified squamous epithelium. Although PV infections in the various Felidae are rarely reported, we identified productive infections in six cat species. PV-induced proliferative skin or mucous membrane lesions were confirmed by immunohistochemical screening for papillomavirus-specific capsid antigens. Seven monoclonal antibodies, each of which reacts with an immunodominant antigenic determinant of the bovine papillomavirus L1 gene product, revealed that feline PV capsid epitopes were conserved to various degrees. This battery of monoclonal antibodies established differential expression patterns among cutaneous and oral PVs of snow leopards and domestic cats, suggesting that they represent distinct viruses. Clinically, the lesions in all species and anatomic sites were locally extensive and frequently multiple. Histologically, the areas of epidermal hyperplasia were flat with a similarity to benign tumors induced by cutaneotropic, carcinogenic PVs in immunosuppressed human patients. Limited restriction endonuclease analyses of viral genomic DNA confirmed the variability among three viral genomes recovered from available frozen tissue. Because most previous PV isolates have been species specific, these studies suggest that at least eight different cat papillomaviruses inlect the oral cavity (tentative designations: Asian lion, Panthera leo, P1PV; snow leopard, Panthera uncia, PuPV-1; bobcat, Felis rufus, FrPV; Florida panther, Felis concolor, FcPV; clouded leopard, Neofelis nebulosa, NnPV; and domestic cat, Felis domesticus, FdPV-2) or skin (domestic cat, F. domesticus, FdPV-1; and snow leopard, P. uncia, PuPV-2).

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalVeterinary Pathology
Volume37
Issue number1
StatePublished - 2000
Externally publishedYes

Fingerprint

Feline papillomavirus
papilloma
Papillomaviridae
Felidae
Papilloma
Panthera uncia
Cats
cats
Neofelis nebulosa
Puma
Lions
Lynx rufus
Puma concolor
capsid
Capsid
Panthera leo
skin (animal)
lesions (animal)
Skin
epitopes

Keywords

  • Bobcats
  • Cats
  • Domestic cats
  • Feline
  • Leopards
  • Lions
  • Oral mucosa
  • Panthers
  • Papillomavirus
  • Skin

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Sundberg, J. P., Van Ranst, M., Montali, R., Homer, B. L., Miller, W. H., Rowland, P. H., ... Jenson, A. B. (2000). Feline Papillomas and Papillomaviruses. Veterinary Pathology, 37(1), 1-10.

Feline Papillomas and Papillomaviruses. / Sundberg, J. P.; Van Ranst, M.; Montali, R.; Homer, B. L.; Miller, W. H.; Rowland, P. H.; Scott, D. W.; England, J. J.; Dunstan, R. W.; Mikaelian, I.; Jenson, A. B.

In: Veterinary Pathology, Vol. 37, No. 1, 2000, p. 1-10.

Research output: Contribution to journalArticle

Sundberg, JP, Van Ranst, M, Montali, R, Homer, BL, Miller, WH, Rowland, PH, Scott, DW, England, JJ, Dunstan, RW, Mikaelian, I & Jenson, AB 2000, 'Feline Papillomas and Papillomaviruses', Veterinary Pathology, vol. 37, no. 1, pp. 1-10.
Sundberg JP, Van Ranst M, Montali R, Homer BL, Miller WH, Rowland PH et al. Feline Papillomas and Papillomaviruses. Veterinary Pathology. 2000;37(1):1-10.
Sundberg, J. P. ; Van Ranst, M. ; Montali, R. ; Homer, B. L. ; Miller, W. H. ; Rowland, P. H. ; Scott, D. W. ; England, J. J. ; Dunstan, R. W. ; Mikaelian, I. ; Jenson, A. B. / Feline Papillomas and Papillomaviruses. In: Veterinary Pathology. 2000 ; Vol. 37, No. 1. pp. 1-10.
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abstract = "Papillomaviruses (PVs) are highly species- and site-specific pathogens of stratified squamous epithelium. Although PV infections in the various Felidae are rarely reported, we identified productive infections in six cat species. PV-induced proliferative skin or mucous membrane lesions were confirmed by immunohistochemical screening for papillomavirus-specific capsid antigens. Seven monoclonal antibodies, each of which reacts with an immunodominant antigenic determinant of the bovine papillomavirus L1 gene product, revealed that feline PV capsid epitopes were conserved to various degrees. This battery of monoclonal antibodies established differential expression patterns among cutaneous and oral PVs of snow leopards and domestic cats, suggesting that they represent distinct viruses. Clinically, the lesions in all species and anatomic sites were locally extensive and frequently multiple. Histologically, the areas of epidermal hyperplasia were flat with a similarity to benign tumors induced by cutaneotropic, carcinogenic PVs in immunosuppressed human patients. Limited restriction endonuclease analyses of viral genomic DNA confirmed the variability among three viral genomes recovered from available frozen tissue. Because most previous PV isolates have been species specific, these studies suggest that at least eight different cat papillomaviruses inlect the oral cavity (tentative designations: Asian lion, Panthera leo, P1PV; snow leopard, Panthera uncia, PuPV-1; bobcat, Felis rufus, FrPV; Florida panther, Felis concolor, FcPV; clouded leopard, Neofelis nebulosa, NnPV; and domestic cat, Felis domesticus, FdPV-2) or skin (domestic cat, F. domesticus, FdPV-1; and snow leopard, P. uncia, PuPV-2).",
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