Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion

Greg M. Delgoffe, Jonathan Powell

Research output: Contribution to journalArticle

Abstract

Through the direct control of infection or by providing cytokine signals to other cellular players, T cells play a central role in the orchestration of the immune response. However, in many disease states, T cells are rendered dysfunctional, unable to carry out their effector functions. As T cell activation is bioenergetically demanding, some T cell dysfunction can have metabolic underpinnings. In this review, we will discuss how T cells are programmed to fuel their effector response, and how programmed or pathologic changes can disrupt their ability to generate the energy needed to proliferate and carry out their critical functions.

Original languageEnglish (US)
Pages (from-to)492-496
Number of pages5
JournalMolecular Immunology
Volume68
Issue number2
DOIs
StatePublished - Dec 1 2015

Fingerprint

T-Lymphocytes
Infection Control
Cytokines

Keywords

  • Anergy
  • Exhaustion
  • Metabolism
  • mTOR
  • T cells
  • Tolerance

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Feeding an army : The metabolism of T cells in activation, anergy, and exhaustion. / Delgoffe, Greg M.; Powell, Jonathan.

In: Molecular Immunology, Vol. 68, No. 2, 01.12.2015, p. 492-496.

Research output: Contribution to journalArticle

@article{e85ce66b523e44f981c884fe8bf73eb1,
title = "Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion",
abstract = "Through the direct control of infection or by providing cytokine signals to other cellular players, T cells play a central role in the orchestration of the immune response. However, in many disease states, T cells are rendered dysfunctional, unable to carry out their effector functions. As T cell activation is bioenergetically demanding, some T cell dysfunction can have metabolic underpinnings. In this review, we will discuss how T cells are programmed to fuel their effector response, and how programmed or pathologic changes can disrupt their ability to generate the energy needed to proliferate and carry out their critical functions.",
keywords = "Anergy, Exhaustion, Metabolism, mTOR, T cells, Tolerance",
author = "Delgoffe, {Greg M.} and Jonathan Powell",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.molimm.2015.07.026",
language = "English (US)",
volume = "68",
pages = "492--496",
journal = "Molecular Immunology",
issn = "0161-5890",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Feeding an army

T2 - The metabolism of T cells in activation, anergy, and exhaustion

AU - Delgoffe, Greg M.

AU - Powell, Jonathan

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Through the direct control of infection or by providing cytokine signals to other cellular players, T cells play a central role in the orchestration of the immune response. However, in many disease states, T cells are rendered dysfunctional, unable to carry out their effector functions. As T cell activation is bioenergetically demanding, some T cell dysfunction can have metabolic underpinnings. In this review, we will discuss how T cells are programmed to fuel their effector response, and how programmed or pathologic changes can disrupt their ability to generate the energy needed to proliferate and carry out their critical functions.

AB - Through the direct control of infection or by providing cytokine signals to other cellular players, T cells play a central role in the orchestration of the immune response. However, in many disease states, T cells are rendered dysfunctional, unable to carry out their effector functions. As T cell activation is bioenergetically demanding, some T cell dysfunction can have metabolic underpinnings. In this review, we will discuss how T cells are programmed to fuel their effector response, and how programmed or pathologic changes can disrupt their ability to generate the energy needed to proliferate and carry out their critical functions.

KW - Anergy

KW - Exhaustion

KW - Metabolism

KW - mTOR

KW - T cells

KW - Tolerance

UR - http://www.scopus.com/inward/record.url?scp=84949530978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949530978&partnerID=8YFLogxK

U2 - 10.1016/j.molimm.2015.07.026

DO - 10.1016/j.molimm.2015.07.026

M3 - Article

C2 - 26256793

AN - SCOPUS:84949530978

VL - 68

SP - 492

EP - 496

JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

IS - 2

ER -