Feed your head: Neurodevelopmental control of feeding and metabolism

Daniel A. Lee, Seth Blackshaw

Research output: Contribution to journalReview article

Abstract

During critical periods of development early in life, excessive or scarce nutritional environments can disrupt the development of central feeding and metabolic neural circuitry, leading to obesity and metabolic disorders in adulthood. A better understanding of the genetic networks that control the development of feeding and metabolic neural circuits, along with knowledge of how and where dietary signals disrupt this process, can serve as the basis for future therapies aimed at reversing the public health crisis that is now building as a result of the global obesity epidemic. This review of animal and human studies highlights recent insights into the molecular mechanisms that regulate the development of central feeding circuitries, the mechanisms by which gestational and early postnatal nutritional status affects this process, and approaches aimed at counteracting the deleterious effects of early over- and underfeeding. ©

Original languageEnglish (US)
Pages (from-to)197-223
Number of pages27
JournalAnnual review of physiology
Volume76
DOIs
StatePublished - Feb 1 2014

Keywords

  • Diabetes
  • Diet
  • Hypothalamus
  • Neural circuits
  • Neurogenesis
  • Obesity

ASJC Scopus subject areas

  • Physiology

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