Fecal immunoglobulin a against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban Bangladesh: A prospective cohort study

Kevin L. Steiner; Mamun Kabir; Jeffrey W. Priest; Biplob Hossain; Carol A. Gilchrist; Heather Cook; Jennie Z. Ma; Poonum S. Korpe; Tahmeed Ahmed; A. S.G. Faruque; Rashidul Haque; William A. Petri

doi:10.1093/cid/ciz430

Fecal immunoglobulin a against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban Bangladesh: A prospective cohort study

Kevin L. Steiner, Mamun Kabir, Jeffrey W. Priest, Biplob Hossain, Carol A. Gilchrist, Heather Cook, Jennie Z. Ma, Poonum S. Korpe, Tahmeed Ahmed, A. S.G. Faruque, Rashidul Haque, William A. Petri

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In this prospective cohort study of Bangladeshi children, greater 7fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

Original language	English (US)
Pages (from-to)	323-326
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	70
Issue number	2
DOIs	https://doi.org/10.1093/cid/ciz430
State	Published - Jan 15 2020

Keywords

Cp23
Cryptosporidiosis
Fecal
IgA
Mucosal

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciz430

Cite this

Steiner, K. L., Kabir, M., Priest, J. W., Hossain, B., Gilchrist, C. A., Cook, H., Ma, J. Z., Korpe, P. S., Ahmed, T., Faruque, A. S. G., Haque, R., & Petri, W. A. (2020). Fecal immunoglobulin a against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban Bangladesh: A prospective cohort study. Clinical Infectious Diseases, 70(2), 323-326. https://doi.org/10.1093/cid/ciz430

Fecal immunoglobulin a against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban Bangladesh: A prospective cohort study. / Steiner, Kevin L.; Kabir, Mamun; Priest, Jeffrey W. et al.
In: Clinical Infectious Diseases, Vol. 70, No. 2, 15.01.2020, p. 323-326.

Research output: Contribution to journal › Article › peer-review

Steiner, KL, Kabir, M, Priest, JW, Hossain, B, Gilchrist, CA, Cook, H, Ma, JZ, Korpe, PS, Ahmed, T, Faruque, ASG, Haque, R & Petri, WA 2020, 'Fecal immunoglobulin a against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban Bangladesh: A prospective cohort study', Clinical Infectious Diseases, vol. 70, no. 2, pp. 323-326. https://doi.org/10.1093/cid/ciz430

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abstract = "In this prospective cohort study of Bangladeshi children, greater 7fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.",

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AU - Gilchrist, Carol A.

AU - Cook, Heather

AU - Ma, Jennie Z.

AU - Korpe, Poonum S.

AU - Ahmed, Tahmeed

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AU - Haque, Rashidul

AU - Petri, William A.

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Fecal immunoglobulin a against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban Bangladesh: A prospective cohort study

Abstract

Keywords

ASJC Scopus subject areas

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