Fecal immunoglobulin a against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban Bangladesh: A prospective cohort study

Kevin L. Steiner, Mamun Kabir, Jeffrey W. Priest, Biplob Hossain, Carol A. Gilchrist, Heather Cook, Jennie Z. Ma, Poonum S. Korpe, Tahmeed Ahmed, A. S.G. Faruque, Rashidul Haque, William A. Petri

Research output: Contribution to journalArticlepeer-review

Abstract

In this prospective cohort study of Bangladeshi children, greater 7fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

Original languageEnglish (US)
Pages (from-to)323-326
Number of pages4
JournalClinical Infectious Diseases
Volume70
Issue number2
DOIs
StatePublished - Jan 15 2020

Keywords

  • Cp23
  • Cryptosporidiosis
  • Fecal
  • IgA
  • Mucosal

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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