TY - JOUR
T1 - Fecal excretion of cytomegalovirus in disseminated cytomegalic inclusion disease
AU - Cox, F.
AU - Hughes, W. T.
N1 - Funding Information:
This work was supported by the Childhood Cancer Research Center grant no. CA08480, by multidisciplinary Cancer Research training grant no. CA-05176 from the National Cancer Institute, by General Research Support grant no. RR-055841 from the Division of Research Resources, National Institutes of Health, and by American-Lebanese-Syrian Associated Charities, Indianapolis, Indiana.
PY - 1974
Y1 - 1974
N2 - Urine and rectal cultures were obtained at monthly intervals for three to 10 months from 36 children with complement fixing antibody to cytomegalovirus (titer, ≥ 1:8). Thirty two (89%) of the patients excreted CMV in their urine, and three (8.4%) excreted the virus in their feces. Virus was found in the saliva of 13 patients (36%) and was present in saliva each time a fecal isolate was obtained. Two patients with leukemia and an infant with congenital cytomegalic inclusion disease excreted cytomegalovirus in their feces. The fecal shedding of virus was intermittent and related to disseminated cytomegalic inclusion disease in all three patients and to viremia in two patients. One patient had gastrointestinal symptoms of diarrhea, with the diagnosis confirmed pathologically by rectal mucosal biopsy. This is the first time cytomegalovirus has been isolated from feces, and now the fecal oral route must be considered in the spread of infection. In addition, all patients who excreted cytomegalovirus in their feces had generalized cytomegalic inclusion disease, but none of the patients excreting cytomegalovirus from other sites showed evidence of disease.
AB - Urine and rectal cultures were obtained at monthly intervals for three to 10 months from 36 children with complement fixing antibody to cytomegalovirus (titer, ≥ 1:8). Thirty two (89%) of the patients excreted CMV in their urine, and three (8.4%) excreted the virus in their feces. Virus was found in the saliva of 13 patients (36%) and was present in saliva each time a fecal isolate was obtained. Two patients with leukemia and an infant with congenital cytomegalic inclusion disease excreted cytomegalovirus in their feces. The fecal shedding of virus was intermittent and related to disseminated cytomegalic inclusion disease in all three patients and to viremia in two patients. One patient had gastrointestinal symptoms of diarrhea, with the diagnosis confirmed pathologically by rectal mucosal biopsy. This is the first time cytomegalovirus has been isolated from feces, and now the fecal oral route must be considered in the spread of infection. In addition, all patients who excreted cytomegalovirus in their feces had generalized cytomegalic inclusion disease, but none of the patients excreting cytomegalovirus from other sites showed evidence of disease.
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U2 - 10.1093/infdis/129.6.732
DO - 10.1093/infdis/129.6.732
M3 - Article
C2 - 4365949
AN - SCOPUS:0016212748
SN - 0022-1899
VL - 129
SP - 732
EP - 736
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -