Features and Prognostic Significance of Intraductal Carcinoma of the Prostate

Rodolfo Montironi, Ming Zhou, Cristina Magi-Galluzzi, Jonathan Ira Epstein

Research output: Contribution to journalReview article

Abstract

CONTEXT: Intraductal carcinoma of the prostate (IDC-P) is an intraglandular/ductal neoplastic growth of glandular epithelial cells characterized by marked abnormality of the glandular architecture and/or cytological atypia that exceeds what is typically seen in high-grade prostatic intraepithelial neoplasia (HPGIN). It has been shown that IDC-P is a strong independent indicator of poor prognosis for prostate carcinoma (PCa). OBJECTIVE: To review the pathological and genetic features, diagnostic criteria and differential diagnosis, and clinical significance of IDC-P. EVIDENCE ACQUISITION: PubMed was searched using keywords including prostate carcinoma, intraductal carcinoma, IDC, histology, diagnostic criteria, and prognosis. The references in relevant articles were also reviewed. EVIDENCE SYNTHESIS: IDC-P is a distinct entity with characteristic morphological and genetic features. It is strongly associated with aggressive PCa with high Gleason score/grade groups and large tumor volume, and portends unfavorable clinical outcomes. Morphological diagnostic criteria have been established to distinguish it from other lesions with similar histological features. IDC-P is an uncommon finding in prostate biopsies, and is even rarer as an isolated finding without concomitant PCa. However, patients with isolated IDC-P in biopsy specimens are recommended to have either definitive treatment or immediate repeat biopsy. CONCLUSIONS: It is critical to recognize and report IDC-P, especially in prostate biopsies, where the clinical impact of such a diagnosis is greatest. PATIENT SUMMARY: Intraductal carcinoma is a unique form of aggressive prostate cancer. In this report, we review its pathological and genetic features and poor prognostic significance. It is critical for pathologists to recognize and report this lesion in prostate specimens, especially in prostate biopsies for patient management.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalEuropean urology oncology
Volume1
Issue number1
DOIs
StatePublished - May 1 2018

Fingerprint

Carcinoma, Intraductal, Noninfiltrating
Prostate
Biopsy
Carcinoma
Prostatic Intraepithelial Neoplasia
Neoplasm Grading
Tumor Burden
PubMed

Keywords

  • Diagnosis
  • Intraductal carcinoma
  • Prognosis
  • Prostate carcinoma

Cite this

Features and Prognostic Significance of Intraductal Carcinoma of the Prostate. / Montironi, Rodolfo; Zhou, Ming; Magi-Galluzzi, Cristina; Epstein, Jonathan Ira.

In: European urology oncology, Vol. 1, No. 1, 01.05.2018, p. 21-28.

Research output: Contribution to journalReview article

Montironi, Rodolfo ; Zhou, Ming ; Magi-Galluzzi, Cristina ; Epstein, Jonathan Ira. / Features and Prognostic Significance of Intraductal Carcinoma of the Prostate. In: European urology oncology. 2018 ; Vol. 1, No. 1. pp. 21-28.
@article{b79223f6e6204c30b6b296b9156d326c,
title = "Features and Prognostic Significance of Intraductal Carcinoma of the Prostate",
abstract = "CONTEXT: Intraductal carcinoma of the prostate (IDC-P) is an intraglandular/ductal neoplastic growth of glandular epithelial cells characterized by marked abnormality of the glandular architecture and/or cytological atypia that exceeds what is typically seen in high-grade prostatic intraepithelial neoplasia (HPGIN). It has been shown that IDC-P is a strong independent indicator of poor prognosis for prostate carcinoma (PCa). OBJECTIVE: To review the pathological and genetic features, diagnostic criteria and differential diagnosis, and clinical significance of IDC-P. EVIDENCE ACQUISITION: PubMed was searched using keywords including prostate carcinoma, intraductal carcinoma, IDC, histology, diagnostic criteria, and prognosis. The references in relevant articles were also reviewed. EVIDENCE SYNTHESIS: IDC-P is a distinct entity with characteristic morphological and genetic features. It is strongly associated with aggressive PCa with high Gleason score/grade groups and large tumor volume, and portends unfavorable clinical outcomes. Morphological diagnostic criteria have been established to distinguish it from other lesions with similar histological features. IDC-P is an uncommon finding in prostate biopsies, and is even rarer as an isolated finding without concomitant PCa. However, patients with isolated IDC-P in biopsy specimens are recommended to have either definitive treatment or immediate repeat biopsy. CONCLUSIONS: It is critical to recognize and report IDC-P, especially in prostate biopsies, where the clinical impact of such a diagnosis is greatest. PATIENT SUMMARY: Intraductal carcinoma is a unique form of aggressive prostate cancer. In this report, we review its pathological and genetic features and poor prognostic significance. It is critical for pathologists to recognize and report this lesion in prostate specimens, especially in prostate biopsies for patient management.",
keywords = "Diagnosis, Intraductal carcinoma, Prognosis, Prostate carcinoma",
author = "Rodolfo Montironi and Ming Zhou and Cristina Magi-Galluzzi and Epstein, {Jonathan Ira}",
year = "2018",
month = "5",
day = "1",
doi = "10.1016/j.euo.2018.03.013",
language = "English (US)",
volume = "1",
pages = "21--28",
journal = "European urology oncology",
issn = "2588-9311",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Features and Prognostic Significance of Intraductal Carcinoma of the Prostate

AU - Montironi, Rodolfo

AU - Zhou, Ming

AU - Magi-Galluzzi, Cristina

AU - Epstein, Jonathan Ira

PY - 2018/5/1

Y1 - 2018/5/1

N2 - CONTEXT: Intraductal carcinoma of the prostate (IDC-P) is an intraglandular/ductal neoplastic growth of glandular epithelial cells characterized by marked abnormality of the glandular architecture and/or cytological atypia that exceeds what is typically seen in high-grade prostatic intraepithelial neoplasia (HPGIN). It has been shown that IDC-P is a strong independent indicator of poor prognosis for prostate carcinoma (PCa). OBJECTIVE: To review the pathological and genetic features, diagnostic criteria and differential diagnosis, and clinical significance of IDC-P. EVIDENCE ACQUISITION: PubMed was searched using keywords including prostate carcinoma, intraductal carcinoma, IDC, histology, diagnostic criteria, and prognosis. The references in relevant articles were also reviewed. EVIDENCE SYNTHESIS: IDC-P is a distinct entity with characteristic morphological and genetic features. It is strongly associated with aggressive PCa with high Gleason score/grade groups and large tumor volume, and portends unfavorable clinical outcomes. Morphological diagnostic criteria have been established to distinguish it from other lesions with similar histological features. IDC-P is an uncommon finding in prostate biopsies, and is even rarer as an isolated finding without concomitant PCa. However, patients with isolated IDC-P in biopsy specimens are recommended to have either definitive treatment or immediate repeat biopsy. CONCLUSIONS: It is critical to recognize and report IDC-P, especially in prostate biopsies, where the clinical impact of such a diagnosis is greatest. PATIENT SUMMARY: Intraductal carcinoma is a unique form of aggressive prostate cancer. In this report, we review its pathological and genetic features and poor prognostic significance. It is critical for pathologists to recognize and report this lesion in prostate specimens, especially in prostate biopsies for patient management.

AB - CONTEXT: Intraductal carcinoma of the prostate (IDC-P) is an intraglandular/ductal neoplastic growth of glandular epithelial cells characterized by marked abnormality of the glandular architecture and/or cytological atypia that exceeds what is typically seen in high-grade prostatic intraepithelial neoplasia (HPGIN). It has been shown that IDC-P is a strong independent indicator of poor prognosis for prostate carcinoma (PCa). OBJECTIVE: To review the pathological and genetic features, diagnostic criteria and differential diagnosis, and clinical significance of IDC-P. EVIDENCE ACQUISITION: PubMed was searched using keywords including prostate carcinoma, intraductal carcinoma, IDC, histology, diagnostic criteria, and prognosis. The references in relevant articles were also reviewed. EVIDENCE SYNTHESIS: IDC-P is a distinct entity with characteristic morphological and genetic features. It is strongly associated with aggressive PCa with high Gleason score/grade groups and large tumor volume, and portends unfavorable clinical outcomes. Morphological diagnostic criteria have been established to distinguish it from other lesions with similar histological features. IDC-P is an uncommon finding in prostate biopsies, and is even rarer as an isolated finding without concomitant PCa. However, patients with isolated IDC-P in biopsy specimens are recommended to have either definitive treatment or immediate repeat biopsy. CONCLUSIONS: It is critical to recognize and report IDC-P, especially in prostate biopsies, where the clinical impact of such a diagnosis is greatest. PATIENT SUMMARY: Intraductal carcinoma is a unique form of aggressive prostate cancer. In this report, we review its pathological and genetic features and poor prognostic significance. It is critical for pathologists to recognize and report this lesion in prostate specimens, especially in prostate biopsies for patient management.

KW - Diagnosis

KW - Intraductal carcinoma

KW - Prognosis

KW - Prostate carcinoma

UR - http://www.scopus.com/inward/record.url?scp=85066235115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066235115&partnerID=8YFLogxK

U2 - 10.1016/j.euo.2018.03.013

DO - 10.1016/j.euo.2018.03.013

M3 - Review article

VL - 1

SP - 21

EP - 28

JO - European urology oncology

JF - European urology oncology

SN - 2588-9311

IS - 1

ER -