Feasibility of using recipients of health promotional newsletters for post-marketing surveillance

Lucy A. Mead, Daniel E. Ford, Lewis H. Roht, C. L. Beach, Michael J. Klag

Research output: Contribution to journalArticle

Abstract

Achieving an adequate sample size is one of the major difficulties in performing post-marketing observational studies of health outcomes in persons taking specific drug preparations. We assessed the feasibility of recruiting participants for such a study of Cardizem(®) CD from approximately 400,000 U.S. recipients of a health promotion newsletter. A three-page questionnaire was sent to a 2.5% random sample (n = 10,000) of recipients, stratified by geographic region. After two mailings, 2779 (28%) returned the questionnaire. Of the 2779 respondents, 2132 (77%) reported having high blood pressure. Eighty-seven percent indicated a willingness to participate in a long-term prospective study. In a multivariate model, calcium channel blocker (CCB) use was associated with a history of coronary heart disease, duration of hypertension medication use greater than 1 year, a rating of good or excellent hypertension care, higher systolic blood pressure, higher education level, family history of cardiovascular disease, and history of smoking. These results indicate that self-reported CCB users may be at greater risk of cardiovascular heart disease and that it is feasible to use health promotion newsletters as a source of participants in prospective studies of cardiovascular disease. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)653-660
Number of pages8
JournalJournal of Clinical Epidemiology
Volume53
Issue number6
DOIs
StatePublished - Jun 1 2000

Keywords

  • Calcium channel blockers
  • Health promotional newsletters
  • Post-marketing surveillance

ASJC Scopus subject areas

  • Epidemiology

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