FDG PET/CT Manifestation of Rare Widespread Metastatic Chemoradiation-Refractory Thymic Squamous Cell Carcinoma

Aaron VanDreel; Darshan Patel; Rajyasree Emmadi; Yang Lu

doi:10.1097/RLU.0000000000000936

FDG PET/CT Manifestation of Rare Widespread Metastatic Chemoradiation-Refractory Thymic Squamous Cell Carcinoma

Aaron VanDreel, Darshan Patel, Rajyasree Emmadi, Yang Lu

Research output: Contribution to journal › Article › peer-review

Abstract

A 74-year-old man underwent excisional biopsy of an anterior mediastinal mass that revealed squamous cell carcinoma of thymic origin. Immunohistochemistry revealed insulin-like growth factor-1 receptor positivity, which has been associated with worse prognosis. Restaging FDG PET/CT revealed extensive soft tissue and osseous metastases despite surgery and chemoradiation therapy. Patient was then enrolled in a clinical trial with anti-insulin-like growth factor-1 receptor therapy. A 3-month follow-up FDG PET/CT showed disease progression with an increase in size and number of hypermetabolic metastatic lesions, including interval development of multiple new metastases.

Original language	English (US)
Pages (from-to)	899-901
Number of pages	3
Journal	Clinical Nuclear Medicine
Volume	40
Issue number	11
DOIs	https://doi.org/10.1097/RLU.0000000000000936
State	Published - Nov 1 2015
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/RLU.0000000000000936

Cite this

@article{0184fcde96f841f292500b7b3fb218bb,

title = "FDG PET/CT Manifestation of Rare Widespread Metastatic Chemoradiation-Refractory Thymic Squamous Cell Carcinoma",

abstract = "A 74-year-old man underwent excisional biopsy of an anterior mediastinal mass that revealed squamous cell carcinoma of thymic origin. Immunohistochemistry revealed insulin-like growth factor-1 receptor positivity, which has been associated with worse prognosis. Restaging FDG PET/CT revealed extensive soft tissue and osseous metastases despite surgery and chemoradiation therapy. Patient was then enrolled in a clinical trial with anti-insulin-like growth factor-1 receptor therapy. A 3-month follow-up FDG PET/CT showed disease progression with an increase in size and number of hypermetabolic metastatic lesions, including interval development of multiple new metastases. ",

author = "Aaron VanDreel and Darshan Patel and Rajyasree Emmadi and Yang Lu",

year = "2015",

month = nov,

day = "1",

doi = "10.1097/RLU.0000000000000936",

language = "English (US)",

volume = "40",

pages = "899--901",

journal = "Clinical Nuclear Medicine",

issn = "0363-9762",

publisher = "Lippincott Williams and Wilkins",

number = "11",

}

TY - JOUR

T1 - FDG PET/CT Manifestation of Rare Widespread Metastatic Chemoradiation-Refractory Thymic Squamous Cell Carcinoma

AU - VanDreel, Aaron

AU - Patel, Darshan

AU - Emmadi, Rajyasree

AU - Lu, Yang

PY - 2015/11/1

Y1 - 2015/11/1

N2 - A 74-year-old man underwent excisional biopsy of an anterior mediastinal mass that revealed squamous cell carcinoma of thymic origin. Immunohistochemistry revealed insulin-like growth factor-1 receptor positivity, which has been associated with worse prognosis. Restaging FDG PET/CT revealed extensive soft tissue and osseous metastases despite surgery and chemoradiation therapy. Patient was then enrolled in a clinical trial with anti-insulin-like growth factor-1 receptor therapy. A 3-month follow-up FDG PET/CT showed disease progression with an increase in size and number of hypermetabolic metastatic lesions, including interval development of multiple new metastases.

AB - A 74-year-old man underwent excisional biopsy of an anterior mediastinal mass that revealed squamous cell carcinoma of thymic origin. Immunohistochemistry revealed insulin-like growth factor-1 receptor positivity, which has been associated with worse prognosis. Restaging FDG PET/CT revealed extensive soft tissue and osseous metastases despite surgery and chemoradiation therapy. Patient was then enrolled in a clinical trial with anti-insulin-like growth factor-1 receptor therapy. A 3-month follow-up FDG PET/CT showed disease progression with an increase in size and number of hypermetabolic metastatic lesions, including interval development of multiple new metastases.

UR - http://www.scopus.com/inward/record.url?scp=84974674686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974674686&partnerID=8YFLogxK

U2 - 10.1097/RLU.0000000000000936

DO - 10.1097/RLU.0000000000000936

M3 - Article

C2 - 26252330

AN - SCOPUS:84974674686

SN - 0363-9762

VL - 40

SP - 899

EP - 901

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

IS - 11

ER -

FDG PET/CT Manifestation of Rare Widespread Metastatic Chemoradiation-Refractory Thymic Squamous Cell Carcinoma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this