GUNSTIG EFFECT VAN PACLITAXEL (TAXOL) BIJ PATIENTEN MET EEN MET PLATINA VOORBEHANDELD OVARIUMCARCINOOM

Translated title of the contribution: Favourable effect of paclitaxel (Taxol) in patients with platinum pretreated ovarium carcinoma

K. Hoekman, B. V H Huijskes, C. W. Burger, R. H M Verheijen, H. M. Pinedo, J. B. Vermorken

Research output: Contribution to journalArticle

Abstract

Objective: To assess the anti-tumour and side effects of paclitaxel in patients with ovarian carcinoma, after prior treatment with at least one platinum-containing chemotherapy regimen. Design: Phase II study. Setting: Academic Hospital of the Free University, Amsterdam. Method: Fourteen of 55 patients with progressive ovarian carcinoma were treated with 135 mg/m2 and 41 with 175 mg/m2 paclitaxel, 9 patients by 24-hour and 46 by 3-hour intravenous infusion. Results: In 9/55 (16%) patients an objective tumour response was obtained, which was complete in 1 patient. In 19/55 (35%) patients the disease stabilised. The serum CA 125 level was increased in 52 patients. In 33% of the patients the course of the serum CA 125 was an indication of the tumour response. The median duration of response was 8 months (range 4.1-13.1) and the median duration of survival was 11.3 months (range 0.3-28.2). Side effects of paclitaxel treatment were hair-loss, arthralgia and myalgia and neutropenia of short duration. In 76% of patients pre-existing neurosensory symptoms increased mildly or developed de novo. The neurotoxic effect appeared reversible in most instances after discontinuation of the paclitaxel treatment. Conclusion: In this rather unfavourable patient population, paclitaxel induced only 16% objective response. However, more than 50% of the patients did benefit from paclitaxel treatment, as a much larger group had long lasting disease stabilisation without symptoms or had reduction of symptoms. The treatment was well tolerated by most patients.

Translated title of the contributionFavourable effect of paclitaxel (Taxol) in patients with platinum pretreated ovarium carcinoma
Original languageDutch
Pages (from-to)272-278
Number of pages7
JournalNederlands Tijdschrift voor Geneeskunde
Volume139
Issue number6
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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