Favoring the risk-benefit balance for upper extremity transplantation--the Pittsburgh Protocol.

Vijay S. Gorantla; Gerald Brandacher; Stefan Schneeberger; Xin Xiao Zheng; Albert D. Donnenberg; Joseph E. Losee; W. P.Andrew Lee

doi:10.1016/j.hcl.2011.08.008

Favoring the risk-benefit balance for upper extremity transplantation--the Pittsburgh Protocol.

Vijay S. Gorantla, Gerald Brandacher, Stefan Schneeberger, Xin Xiao Zheng, Albert D. Donnenberg, Joseph E. Losee, W. P.Andrew Lee

School of Medicine

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Upper extremity transplantation is an innovative reconstructive strategy with potential of immediate clinical application and the most near-term pay-off for select amputees, allowing reintegration into employment and society. Routine applicability and widespread impact of such strategies for the upper extremity amputees with devastating limb loss could be enabled by implementation of cellular therapies that integrate and unify the concepts of transplant tolerance induction with those of reconstructive transplantation. Such therapies offer the promise of minimizing the risks, maximizing the benefits and optimizing outcomes of these innovative procedures. Copyright Â

Original language	English (US)
Pages (from-to)	511-520, ix-x
Journal	Hand clinics
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.hcl.2011.08.008
State	Published - Nov 2011

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

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10.1016/j.hcl.2011.08.008

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AU - Donnenberg, Albert D.

AU - Losee, Joseph E.

AU - Lee, W. P.Andrew

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AB - Upper extremity transplantation is an innovative reconstructive strategy with potential of immediate clinical application and the most near-term pay-off for select amputees, allowing reintegration into employment and society. Routine applicability and widespread impact of such strategies for the upper extremity amputees with devastating limb loss could be enabled by implementation of cellular therapies that integrate and unify the concepts of transplant tolerance induction with those of reconstructive transplantation. Such therapies offer the promise of minimizing the risks, maximizing the benefits and optimizing outcomes of these innovative procedures. Copyright Â

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Favoring the risk-benefit balance for upper extremity transplantation--the Pittsburgh Protocol.

Abstract

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