Favorable prognosis associated with hyperdiploidy in children with acute lymphocytic leukemia correlates with extra chromosome 6. A pediatric oncology group study

J. F. Jackson, J. Boyett, J. Pullen, B. Brock, R. Patterson, V. Land, M. Borowitz, D. Head, W. Crist

Research output: Contribution to journalArticle

Abstract

Pretreatment bone marrow cytogenetic studies were included for 1664 patients with acute lymphoblastic leukemia (ALL) accrued to Pediatric Oncology Group (POG) 8035 laboratory classification study from May 1981 through January 1986. There was a significant difference (P = 0.0001) in distribution of stem‐line karyotype (normal, hypodiploid, pseudodiploid, or hyperdiploid) among children with early pre‐B, pre‐B, or T‐cell ALL, with early pre‐B patients demonstrating a higher proportion of hyperdiploid karyotypes with modal chromosome numbers>51. Cytogenetic classification of 1216 patients with early pre‐B or pre‐B ALL evaluable for duration of event‐free survival (EFS), with median follow‐up of 42 months, showed a significant prolongation of five‐year EFS associated with hyperdiploidy>51 (75%; standard error [SE] = 5%) compared with hyperdiploidy 47 to 51 (46%; SE = 7%), hypodiploidy (55%; SE = 11%), and pseudodiploidy (45%; SE = 7%) (P = 0.0001). Five‐year EFS was intermediate for patients with normal (58%), constitutionally abnormal (66%), or unsuccessful analyses (66%). The breakpoint defining hyperdiploidy associated with better prognosis was best defined as>51 (P = 0.0002). Of 239 children with hyperdiploid karyotypes, analysis of the contribution of each chromosome to EFS duration showed a significant association between improved EFS and additional chromosome(s) six (P = 0.02). Chromosome translocation was associated with shorter EFS (P = 0.0001).

Original languageEnglish (US)
Pages (from-to)1183-1189
Number of pages7
JournalCancer
Volume66
Issue number6
DOIs
StatePublished - Sep 15 1990

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Favorable prognosis associated with hyperdiploidy in children with acute lymphocytic leukemia correlates with extra chromosome 6. A pediatric oncology group study'. Together they form a unique fingerprint.

  • Cite this