TY - JOUR
T1 - Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination
AU - Bol, Kalijn F.
AU - Aarntzen, Erik H.J.G.
AU - in ’t Hout, Florentien E.M.
AU - Schreibelt, Gerty
AU - Creemers, Jeroen H.A.
AU - Lesterhuis, W. Joost
AU - Gerritsen, Winald R.
AU - Grunhagen, Dirk J.
AU - Verhoef, Cornelis
AU - Punt, Cornelis J.A.
AU - Bonenkamp, Johannes J.
AU - de Wilt, Johannes H.W.
AU - Figdor, Carl G.
AU - de Vries, I. Jolanda M.
N1 - Publisher Copyright:
© 2016 Taylor & Francis Group, LLC.
PY - 2016
Y1 - 2016
N2 - Melanoma patients with regional metastatic disease are at high risk for recurrence and metastatic disease, despite radical lymph node dissection (RLND). We investigated the immunologic response and clinical outcome to adjuvant dendritic cell (DC) vaccination in melanoma patients with regional metastatic disease who underwent RLND with curative intent. In this retrospective study, 78 melanoma patients with regional lymph node metastasis who underwent RLND received autologous DCs loaded with gp100 and tyrosinase and were analyzed for functional tumor-specific T cell responses in skin-test infiltrating lymphocytes. The study shows that adjuvant DC vaccination in melanoma patients with regional lymph node metastasis is safe and induced functional tumor-specific T cell responses in 71% of the patients. The presence of functional tumor-specific T cells was correlated with a better 2-year overall survival (OS) rate. OS was significantly higher after adjuvant DC vaccination compared to 209 matched controls who underwent RLND without adjuvant DC vaccination, 63.6 mo vs. 31.0 mo (p = 0.018; hazard ratio 0.59; 95%CI 0.42–0.84). Five-year survival rate increased from 38% to 53% (p < 0.01). In summary, in melanoma patients with regional metastatic disease, who are at high risk for recurrence and metastatic disease after RLND, adjuvant DC vaccination is well tolerated. It induced functional tumor-specific immune responses in the majority of patients and these were related to clinical outcome. OS was significantly higher compared to matched controls. A randomized clinical trial is needed to prospectively validate the efficacy of DC vaccination in the adjuvant setting.
AB - Melanoma patients with regional metastatic disease are at high risk for recurrence and metastatic disease, despite radical lymph node dissection (RLND). We investigated the immunologic response and clinical outcome to adjuvant dendritic cell (DC) vaccination in melanoma patients with regional metastatic disease who underwent RLND with curative intent. In this retrospective study, 78 melanoma patients with regional lymph node metastasis who underwent RLND received autologous DCs loaded with gp100 and tyrosinase and were analyzed for functional tumor-specific T cell responses in skin-test infiltrating lymphocytes. The study shows that adjuvant DC vaccination in melanoma patients with regional lymph node metastasis is safe and induced functional tumor-specific T cell responses in 71% of the patients. The presence of functional tumor-specific T cells was correlated with a better 2-year overall survival (OS) rate. OS was significantly higher after adjuvant DC vaccination compared to 209 matched controls who underwent RLND without adjuvant DC vaccination, 63.6 mo vs. 31.0 mo (p = 0.018; hazard ratio 0.59; 95%CI 0.42–0.84). Five-year survival rate increased from 38% to 53% (p < 0.01). In summary, in melanoma patients with regional metastatic disease, who are at high risk for recurrence and metastatic disease after RLND, adjuvant DC vaccination is well tolerated. It induced functional tumor-specific immune responses in the majority of patients and these were related to clinical outcome. OS was significantly higher compared to matched controls. A randomized clinical trial is needed to prospectively validate the efficacy of DC vaccination in the adjuvant setting.
KW - Adjuvant therapy
KW - Dendritic cell
KW - Immunotherapy
KW - Melanoma
KW - Vaccination
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U2 - 10.1080/2162402X.2015.1057673
DO - 10.1080/2162402X.2015.1057673
M3 - Article
C2 - 26942068
AN - SCOPUS:84954456996
SN - 2162-4011
VL - 5
JO - OncoImmunology
JF - OncoImmunology
IS - 1
ER -