Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-α nuclear receptors

Carmen Mazzola, Julie Medalie, Maria Scherma, Leigh V. Panlilio, Marcello Solinas, Gianluigi Tanda, Filippo Drago, Jean Lud Cadet, Steven R. Goldberg, Sevil Yasar

Research output: Contribution to journalArticlepeer-review

Abstract

Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of anandamide (a cannabinoid CB1-receptor ligand) and oleoylethanolamide and palmitoylethanolamide (OEA and PEA, ligands for α-type peroxisome proliferator-activated nuclear receptors, PPAR-α) when and where they are naturally released in the brain. Using a passive-avoidance task in rats, we found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-α agonist WY14643, and these enhancements were blocked by the PPAR-α antagonist MK886. These findings demonstrate novel mechanisms for memory enhancement by activation of PPAR-α, either directly by administering a PPAR-α agonist or indirectly by administering a FAAH inhibitor.

Original languageEnglish (US)
Pages (from-to)332-337
Number of pages6
JournalLearning and Memory
Volume16
Issue number5
DOIs
StatePublished - May 2009

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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