Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-α nuclear receptors

Carmen Mazzola; Julie Medalie; Maria Scherma; Leigh V. Panlilio; Marcello Solinas; Gianluigi Tanda; Filippo Drago; Jean Lud Cadet; Steven R. Goldberg; Sevil Yasar

doi:10.1101/lm.1145209

Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-α nuclear receptors

Carmen Mazzola, Julie Medalie, Maria Scherma, Leigh V. Panlilio, Marcello Solinas, Gianluigi Tanda, Filippo Drago, Jean Lud Cadet, Steven R. Goldberg, Sevil Yasar

School of Medicine

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of anandamide (a cannabinoid CB₁-receptor ligand) and oleoylethanolamide and palmitoylethanolamide (OEA and PEA, ligands for α-type peroxisome proliferator-activated nuclear receptors, PPAR-α) when and where they are naturally released in the brain. Using a passive-avoidance task in rats, we found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-α agonist WY14643, and these enhancements were blocked by the PPAR-α antagonist MK886. These findings demonstrate novel mechanisms for memory enhancement by activation of PPAR-α, either directly by administering a PPAR-α agonist or indirectly by administering a FAAH inhibitor.

Original language	English (US)
Pages (from-to)	332-337
Number of pages	6
Journal	Learning and Memory
Volume	16
Issue number	5
DOIs	https://doi.org/10.1101/lm.1145209
State	Published - May 2009

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Cellular and Molecular Neuroscience

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10.1101/lm.1145209

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title = "Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-α nuclear receptors",

abstract = "Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of anandamide (a cannabinoid CB1-receptor ligand) and oleoylethanolamide and palmitoylethanolamide (OEA and PEA, ligands for α-type peroxisome proliferator-activated nuclear receptors, PPAR-α) when and where they are naturally released in the brain. Using a passive-avoidance task in rats, we found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-α agonist WY14643, and these enhancements were blocked by the PPAR-α antagonist MK886. These findings demonstrate novel mechanisms for memory enhancement by activation of PPAR-α, either directly by administering a PPAR-α agonist or indirectly by administering a FAAH inhibitor.",

author = "Carmen Mazzola and Julie Medalie and Maria Scherma and Panlilio, {Leigh V.} and Marcello Solinas and Gianluigi Tanda and Filippo Drago and Cadet, {Jean Lud} and Goldberg, {Steven R.} and Sevil Yasar",

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T1 - Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-α nuclear receptors

AU - Mazzola, Carmen

AU - Medalie, Julie

AU - Scherma, Maria

AU - Panlilio, Leigh V.

AU - Solinas, Marcello

AU - Tanda, Gianluigi

AU - Drago, Filippo

AU - Cadet, Jean Lud

AU - Goldberg, Steven R.

AU - Yasar, Sevil

PY - 2009/5

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AB - Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of anandamide (a cannabinoid CB1-receptor ligand) and oleoylethanolamide and palmitoylethanolamide (OEA and PEA, ligands for α-type peroxisome proliferator-activated nuclear receptors, PPAR-α) when and where they are naturally released in the brain. Using a passive-avoidance task in rats, we found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-α agonist WY14643, and these enhancements were blocked by the PPAR-α antagonist MK886. These findings demonstrate novel mechanisms for memory enhancement by activation of PPAR-α, either directly by administering a PPAR-α agonist or indirectly by administering a FAAH inhibitor.

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Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-α nuclear receptors

Abstract

ASJC Scopus subject areas

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