Fate-restricted neural progenitors in the mammalian cerebral cortex

Santos J. Franco, Cristina Gil-Sanz, Isabel Martinez-Garay, Ana Espinosa, Sarah R. Harkins-Perry, Cynthia Ramos, Ulrich Müller

Research output: Contribution to journalArticlepeer-review

Abstract

During development of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower-layer neurons are formed before upper-layer neurons. It has been proposed that neuronal subtype fate is determined by birthdate through progressive restriction of the neurogenic potential of a common RGC progenitor. Here, we demonstrate that the murine cerebral cortex contains RGC sublineages with distinct fate potentials. Using in vivo genetic fate mapping and in vitro clonal analysis, we identified an RGC lineage that is intrinsically specified to generate only upper-layer neurons, independently of niche and birthdate. Because upper cortical layers were expanded during primate evolution, amplification of this RGC pool may have facilitated human brain evolution.

Original languageEnglish (US)
Pages (from-to)746-749
Number of pages4
JournalScience
Volume337
Issue number6095
DOIs
StatePublished - Aug 10 2012
Externally publishedYes

ASJC Scopus subject areas

  • General

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