TY - JOUR
T1 - Fatal West Nile virus infection after rituximab/fludarabine-induced remission for non-Hodgkin's lymphoma
AU - Mawhorter, Steven D.
AU - Sierk, Anne
AU - Staugaitis, Susan M.
AU - Avery, Robin K.
AU - Sobecks, Ronald
AU - Prayson, Richard A.
AU - Procop, Gary W.
AU - Yen-Lieberman, Belinda
PY - 2005/11
Y1 - 2005/11
N2 - West Nile virus (WNV) infections are potentially life threatening in immunocompromised hosts. Currently, the best diagnostic test is serology. Reverse-transcriptase polymerase chain reaction (RT-PCR) testing has a role, but, because WNV is a cell-associated neurotropic virus, RT-PCR results are frequently negative even in cases of active infection. We present a case in which serology results were persistently negative because the patient was immunocompromised following lymphoma treatment. The role of humoral immunity in resolution of WNV is also discussed.
AB - West Nile virus (WNV) infections are potentially life threatening in immunocompromised hosts. Currently, the best diagnostic test is serology. Reverse-transcriptase polymerase chain reaction (RT-PCR) testing has a role, but, because WNV is a cell-associated neurotropic virus, RT-PCR results are frequently negative even in cases of active infection. We present a case in which serology results were persistently negative because the patient was immunocompromised following lymphoma treatment. The role of humoral immunity in resolution of WNV is also discussed.
KW - Diagnosis
KW - Humoral immunity
KW - Immunocompromised patients
KW - Polymerase chain reaction
KW - Serology
UR - http://www.scopus.com/inward/record.url?scp=33644878157&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644878157&partnerID=8YFLogxK
U2 - 10.3816/CLM.2005.n.053
DO - 10.3816/CLM.2005.n.053
M3 - Article
C2 - 16354331
AN - SCOPUS:33644878157
SN - 1557-9190
VL - 6
SP - 248
EP - 250
JO - Clinical Lymphoma and Myeloma
JF - Clinical Lymphoma and Myeloma
IS - 3
ER -