TY - JOUR
T1 - Fatal Seronegative Ehrlichiosis in a Patient with HIV Infection
AU - Paddock, Christopher D.
AU - Suchard, David P.
AU - Grumbach, Kevin L.
AU - Hadley, W. Keith
AU - Kerschmann, Russell L.
AU - Abbey, Nancy W.
AU - Dawson, Jaqueline E.
AU - Anderson, Burt E.
AU - Sims, Kimetha G.
AU - Dumler, J. Stephen
AU - Herndier, Brian G.
PY - 1993/10/14
Y1 - 1993/10/14
N2 - Human infection with Ehrlichia chaffeensis, a recently identified bacterium included in the family Rickettsiaceae,1,2 results in an acute, generally self-limited, febrile illness associated with cytopenia and hepatic-enzyme abnormalities. Several hundred cases of E. chaffeensis infection have been recognized since 1986, although ehrlichiosis has not been described in patients infected with the human immunodeficiency virus (HIV). We report the course of a fatal seronegative ehrlichial infection in a woman with advanced HIV infection. The infection was diagnosed by light and electron microscopy, immunohistochemical techniques, and the polymerase chain reaction. The potential for successful antimicrobial treatment, combined with the possible absence…
AB - Human infection with Ehrlichia chaffeensis, a recently identified bacterium included in the family Rickettsiaceae,1,2 results in an acute, generally self-limited, febrile illness associated with cytopenia and hepatic-enzyme abnormalities. Several hundred cases of E. chaffeensis infection have been recognized since 1986, although ehrlichiosis has not been described in patients infected with the human immunodeficiency virus (HIV). We report the course of a fatal seronegative ehrlichial infection in a woman with advanced HIV infection. The infection was diagnosed by light and electron microscopy, immunohistochemical techniques, and the polymerase chain reaction. The potential for successful antimicrobial treatment, combined with the possible absence…
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U2 - 10.1056/NEJM199310143291605
DO - 10.1056/NEJM199310143291605
M3 - Article
C2 - 8377780
AN - SCOPUS:0027363721
SN - 0028-4793
VL - 329
SP - 1164
EP - 1167
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 16
ER -