Fatal outcome in Japanese encephalitis

D. S. Burke, W. Lorsomrudee, C. J. Leake, C. H. Hoke, A. Nisalak, V. Chongswasdi, T. Laorakpongse

Research output: Contribution to journalArticlepeer-review


Forty-nine consecutive patients with laboratory-confirmed acute Japanese encephalitis were studied to identify risk factors present at hospital admission which were associated with a fatal outcome. Sixteen patients (33%) died. The following constellation of findings correlated with a fatal outcome: infectious virus in cerebrospinal fluid (CSF), low levels of Japanese encephalitis virus-specific IgG and IgM in both CSF and serum and a severely depressed sensorium. Age, sex, days ill before admission, distance from home to the hospital, past medical history, CSF protein content, and CSF leukocyte count were not significant risk factors. Among patients hospitalized for acute Japanese encephalitis, a vigorous virus-specific immunoglobulin response, both systemically and locally within the central nervous system, is a good marker for survival, and may be an inherently important factor in recovery from illness.

Original languageEnglish (US)
Pages (from-to)1203-1210
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number6
StatePublished - 1985

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases


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