Fatal disseminated adenoviral infection associated with thrombotic thrombocytopenic purpura after allogeneic bone marrow transplantation

A. B.T. Fassas, L. N. Buddharaju, A. Rapoport, M. Cottler-Fox, C. Drachenberg, B. Meisenberg, G. Tricot

Research output: Contribution to journalArticle

Abstract

Adenoviruses are increasingly recognized as a significant cause of morbidity and mortality in immunocompromised patients. We report on a patient who, approximately 4 weeks after allogeneic stem cell transplantation, developed fever, new liver lesions and thrombotic microangiopathy. Adenovirus type 2 was isolated from blood and urine samples. Liver biopsy showed parenchymal necrosis with intranuclear viral inclusion bodies. Immunohistochemistry was positive for adenovirus. In addition, on electron microscopy the morphologic pattern was highly suggestive of adenovirus. The patient died on post-transplant day 40. The relatively early post-transplant presentation of disseminated adenoviral disease and its possible association with a TTP-like picture are rather unusual after allogeneic transplantation.

Original languageEnglish (US)
Pages (from-to)801-804
Number of pages4
JournalLeukemia and Lymphoma
Volume42
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Adenovirus
  • Bone marrow transplant
  • Disseminated infection
  • Thrombotic microangiopathy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Fassas, A. B. T., Buddharaju, L. N., Rapoport, A., Cottler-Fox, M., Drachenberg, C., Meisenberg, B., & Tricot, G. (2001). Fatal disseminated adenoviral infection associated with thrombotic thrombocytopenic purpura after allogeneic bone marrow transplantation. Leukemia and Lymphoma, 42(4), 801-804. https://doi.org/10.3109/10428190109099343