Abstract
Twenty-three children with heterozygous familial hypercholesterolemia were studied to determine whether long-term administration of colestipol hydrochloride in conjunction with a low-cholesterol diet would be effective in reducing plasma total and low density lipoprotein cholesterol and would affect the plasma concentrations of vitamins A, D, E, K or folic acid. Effect of the drug on calcium metabolism was studied by sequential determination of serum total and ionized calcium, phosphorus, alkaline phosphatase, and parathyroid hormone. Mean decrease in plasma cholesterol of children previously on ad libitum diets was 6% after 3 mth of diet. After 2 mth of colestipol therapy and diet in the 11 children with good drug adherence, total cholesterol decreased 19±3% (SEM) from drug baseline; after 2 yr of therapy in 5 of these children, mean decrease from drug baseline was 13±5%. Diet did not significantly decrease serum concentration of any of the vitamins but during 24 mth of colestipol therapy serum vitamin A and E concentrations did decrease in the 5 patients with good drug adherence (vitamin A, 68±11 vs 35±4 μg/100 ml, P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 243-250 |
| Number of pages | 8 |
| Journal | Pediatrics |
| Volume | 65 |
| Issue number | 2 |
| State | Published - 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Fat-soluble vitamin concentrations in hypercholesterolemic children treated with colestipol. / Schwarz, Kathleen; Goldstein, P. D.; Witztum, J. L.; Schonfeld, G.
In: Pediatrics, Vol. 65, No. 2, 1980, p. 243-250.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fat-soluble vitamin concentrations in hypercholesterolemic children treated with colestipol
AU - Schwarz, Kathleen
AU - Goldstein, P. D.
AU - Witztum, J. L.
AU - Schonfeld, G.
PY - 1980
Y1 - 1980
N2 - Twenty-three children with heterozygous familial hypercholesterolemia were studied to determine whether long-term administration of colestipol hydrochloride in conjunction with a low-cholesterol diet would be effective in reducing plasma total and low density lipoprotein cholesterol and would affect the plasma concentrations of vitamins A, D, E, K or folic acid. Effect of the drug on calcium metabolism was studied by sequential determination of serum total and ionized calcium, phosphorus, alkaline phosphatase, and parathyroid hormone. Mean decrease in plasma cholesterol of children previously on ad libitum diets was 6% after 3 mth of diet. After 2 mth of colestipol therapy and diet in the 11 children with good drug adherence, total cholesterol decreased 19±3% (SEM) from drug baseline; after 2 yr of therapy in 5 of these children, mean decrease from drug baseline was 13±5%. Diet did not significantly decrease serum concentration of any of the vitamins but during 24 mth of colestipol therapy serum vitamin A and E concentrations did decrease in the 5 patients with good drug adherence (vitamin A, 68±11 vs 35±4 μg/100 ml, P
AB - Twenty-three children with heterozygous familial hypercholesterolemia were studied to determine whether long-term administration of colestipol hydrochloride in conjunction with a low-cholesterol diet would be effective in reducing plasma total and low density lipoprotein cholesterol and would affect the plasma concentrations of vitamins A, D, E, K or folic acid. Effect of the drug on calcium metabolism was studied by sequential determination of serum total and ionized calcium, phosphorus, alkaline phosphatase, and parathyroid hormone. Mean decrease in plasma cholesterol of children previously on ad libitum diets was 6% after 3 mth of diet. After 2 mth of colestipol therapy and diet in the 11 children with good drug adherence, total cholesterol decreased 19±3% (SEM) from drug baseline; after 2 yr of therapy in 5 of these children, mean decrease from drug baseline was 13±5%. Diet did not significantly decrease serum concentration of any of the vitamins but during 24 mth of colestipol therapy serum vitamin A and E concentrations did decrease in the 5 patients with good drug adherence (vitamin A, 68±11 vs 35±4 μg/100 ml, P
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M3 - Article
VL - 65
SP - 243
EP - 250
JO - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 2
ER -