TY - JOUR
T1 - Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans
T2 - A clamp study in sub-Saharan Africans
AU - Sobngwi, Eugene
AU - Kengne, Andre Pascal
AU - Echouffo-Tcheugui, Justin B.
AU - Choukem, Simeon
AU - Sobngwi-Tambekou, Joelle
AU - Balti, Eric V.
AU - Pearce, Mark S.
AU - Siaha, Valentin
AU - Mamdjokam, Aissa S.
AU - Effoe, Valery
AU - Lontchi-Yimagou, Eric
AU - Donfack, Oliver T.
AU - Atogho-Tiedeu, Barbara
AU - Boudou, Philippe
AU - Gautier, Jean Francois
AU - Mbanya, Jean Claude
N1 - Publisher Copyright:
© 2014 Sobngwi et al.; licensee BioMed Central Ltd.
PY - 2014/8/9
Y1 - 2014/8/9
N2 - Background: We aimed to evaluate the predictive utility of common fasting insulin sensitivity indices, and non-laboratory surrogates [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)] in sub-Saharan Africans without diabetes.Methods: We measured fasting glucose and insulin, and glucose uptake during 80/mU/m2/min euglycemic clamp in 87 Cameroonians (51 men) aged (SD) 34.6 (11.4) years. We derived insulin sensitivity indices including HOMA-IR, quantitative insulin sensitivity check index (QUICKI), fasting insulin resistance index (FIRI) and glucose-to-insulin ratio (GIR). Indices and clinical predictors were compared to clamp using correlation tests, robust linear regressions and agreement of classification by sex-specific thirds.Results: The mean insulin sensitivity was M = 10.5 ± 3.2 mg/kg/min. Classification across thirds of insulin sensitivity by clamp matched with non-laboratory surrogates in 30-48% of participants, and with fasting indices in 27-51%, with kappa statistics ranging from -0.10 to 0.26. Fasting indices correlated significantly with clamp (/r/=0.23-0.30), with GIR performing less well than fasting insulin and HOMA-IR (both p < 0.02). BMI, WC and WHtR were equal or superior to fasting indices (/r/=0.38-0.43). Combinations of fasting indices and clinical predictors explained 25-27% of variation in clamp values.Conclusion: Fasting insulin sensitivity indices are modest predictors of insulin sensitivity measured by euglycemic clamp, and do not perform better than clinical surrogates in this population.
AB - Background: We aimed to evaluate the predictive utility of common fasting insulin sensitivity indices, and non-laboratory surrogates [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)] in sub-Saharan Africans without diabetes.Methods: We measured fasting glucose and insulin, and glucose uptake during 80/mU/m2/min euglycemic clamp in 87 Cameroonians (51 men) aged (SD) 34.6 (11.4) years. We derived insulin sensitivity indices including HOMA-IR, quantitative insulin sensitivity check index (QUICKI), fasting insulin resistance index (FIRI) and glucose-to-insulin ratio (GIR). Indices and clinical predictors were compared to clamp using correlation tests, robust linear regressions and agreement of classification by sex-specific thirds.Results: The mean insulin sensitivity was M = 10.5 ± 3.2 mg/kg/min. Classification across thirds of insulin sensitivity by clamp matched with non-laboratory surrogates in 30-48% of participants, and with fasting indices in 27-51%, with kappa statistics ranging from -0.10 to 0.26. Fasting indices correlated significantly with clamp (/r/=0.23-0.30), with GIR performing less well than fasting insulin and HOMA-IR (both p < 0.02). BMI, WC and WHtR were equal or superior to fasting indices (/r/=0.38-0.43). Combinations of fasting indices and clinical predictors explained 25-27% of variation in clamp values.Conclusion: Fasting insulin sensitivity indices are modest predictors of insulin sensitivity measured by euglycemic clamp, and do not perform better than clinical surrogates in this population.
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U2 - 10.1186/1472-6823-14-65
DO - 10.1186/1472-6823-14-65
M3 - Article
C2 - 25106496
AN - SCOPUS:84905923981
SN - 1472-6823
VL - 14
JO - BMC Endocrine Disorders
JF - BMC Endocrine Disorders
IS - 1
M1 - 65
ER -