TY - JOUR
T1 - Fasting blood glucose and insulin sensitivity are unaffected by HAART duration in Cameroonians receiving first-line antiretroviral treatment
AU - Ekali, L. G.
AU - Johnstone, L. K.
AU - Echouffo-Tcheugui, J. B.
AU - Kouanfack, C.
AU - Dehayem, M. Y.
AU - Fezeu, L.
AU - Nouthe, B.
AU - Hayes, L.
AU - Unwin, N. C.
AU - Sobngwi, E.
PY - 2013
Y1 - 2013
N2 - Aims: This study assessed the relationship between highly active antiretroviral therapy (HAART) duration and cardiometabolic disorders in HIV-infected Cameroonians. Methods: HIV-infected Cameroonians aged 21 years or above were cross-sectionally recruited at the Yaoundé Central Hospital, a certified HIV care centre, and their anthropometry, body composition (impedancemetry), fasting blood glucose (FBG) and lipid levels, and insulin sensitivity (IS; short insulin tolerance test) were measured. Results: A total of 143 participants with various durations of HAART [treatment-naïve (n= 28), 1-13 months (n= 44), 14-33 months (n= 35) and 34-86 months (n= 36)] were recruited. They were mostly women (72%), and had a mean age of 39.5 (SD: 9.8) years. Half (52%) were using a stavudine-containing regimen. There was a significant trend towards a positive change in body mass index and waist-to-hip ratio with increasing duration of HAART (all P= 0.02). Systolic (P= 0.04) and diastolic (P= 0.03) blood pressure, total cholesterol (P= 0.01), prevalence of hypertension (P= 0.04) and hypercholesterolaemia (P= 0.007) were also significantly increased with HAART duration, whereas triglycerides, FBG and IS were unaffected. Clustering of metabolic disorders increased (P= 0.02 for ≥ 1 component of the metabolic syndrome and P= 0.09 for ≥ 2 components) with HAART duration. Conclusion: HAART duration is associated with obesity, fat distribution, blood pressure and cholesterol levels in HIV-infected Cameroonians, but does not appear to significantly affect glucose metabolism.
AB - Aims: This study assessed the relationship between highly active antiretroviral therapy (HAART) duration and cardiometabolic disorders in HIV-infected Cameroonians. Methods: HIV-infected Cameroonians aged 21 years or above were cross-sectionally recruited at the Yaoundé Central Hospital, a certified HIV care centre, and their anthropometry, body composition (impedancemetry), fasting blood glucose (FBG) and lipid levels, and insulin sensitivity (IS; short insulin tolerance test) were measured. Results: A total of 143 participants with various durations of HAART [treatment-naïve (n= 28), 1-13 months (n= 44), 14-33 months (n= 35) and 34-86 months (n= 36)] were recruited. They were mostly women (72%), and had a mean age of 39.5 (SD: 9.8) years. Half (52%) were using a stavudine-containing regimen. There was a significant trend towards a positive change in body mass index and waist-to-hip ratio with increasing duration of HAART (all P= 0.02). Systolic (P= 0.04) and diastolic (P= 0.03) blood pressure, total cholesterol (P= 0.01), prevalence of hypertension (P= 0.04) and hypercholesterolaemia (P= 0.007) were also significantly increased with HAART duration, whereas triglycerides, FBG and IS were unaffected. Clustering of metabolic disorders increased (P= 0.02 for ≥ 1 component of the metabolic syndrome and P= 0.09 for ≥ 2 components) with HAART duration. Conclusion: HAART duration is associated with obesity, fat distribution, blood pressure and cholesterol levels in HIV-infected Cameroonians, but does not appear to significantly affect glucose metabolism.
KW - Antiretroviral therapy
KW - Cardiovascular risk factors
KW - Human immunodeficiency virus
KW - Hyperglycaemia
KW - Insulin sensitivity
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U2 - 10.1016/j.diabet.2012.08.012
DO - 10.1016/j.diabet.2012.08.012
M3 - Article
C2 - 23153435
AN - SCOPUS:84874296354
SN - 1262-3636
VL - 39
SP - 71
EP - 77
JO - Diabetes and Metabolism
JF - Diabetes and Metabolism
IS - 1
ER -