Fasting blood glucose and insulin sensitivity are unaffected by HAART duration in Cameroonians receiving first-line antiretroviral treatment

L. G. Ekali, L. K. Johnstone, J. B. Echouffo-Tcheugui, C. Kouanfack, M. Y. Dehayem, L. Fezeu, B. Nouthe, L. Hayes, N. C. Unwin, E. Sobngwi

Research output: Contribution to journalArticle

Abstract

Aims: This study assessed the relationship between highly active antiretroviral therapy (HAART) duration and cardiometabolic disorders in HIV-infected Cameroonians. Methods: HIV-infected Cameroonians aged 21 years or above were cross-sectionally recruited at the Yaoundé Central Hospital, a certified HIV care centre, and their anthropometry, body composition (impedancemetry), fasting blood glucose (FBG) and lipid levels, and insulin sensitivity (IS; short insulin tolerance test) were measured. Results: A total of 143 participants with various durations of HAART [treatment-naïve (n= 28), 1-13 months (n= 44), 14-33 months (n= 35) and 34-86 months (n= 36)] were recruited. They were mostly women (72%), and had a mean age of 39.5 (SD: 9.8) years. Half (52%) were using a stavudine-containing regimen. There was a significant trend towards a positive change in body mass index and waist-to-hip ratio with increasing duration of HAART (all P= 0.02). Systolic (P= 0.04) and diastolic (P= 0.03) blood pressure, total cholesterol (P= 0.01), prevalence of hypertension (P= 0.04) and hypercholesterolaemia (P= 0.007) were also significantly increased with HAART duration, whereas triglycerides, FBG and IS were unaffected. Clustering of metabolic disorders increased (P= 0.02 for ≥ 1 component of the metabolic syndrome and P= 0.09 for ≥ 2 components) with HAART duration. Conclusion: HAART duration is associated with obesity, fat distribution, blood pressure and cholesterol levels in HIV-infected Cameroonians, but does not appear to significantly affect glucose metabolism.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalDiabetes and Metabolism
Volume39
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Keywords

  • Antiretroviral therapy
  • Cardiovascular risk factors
  • Human immunodeficiency virus
  • Hyperglycaemia
  • Insulin sensitivity

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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