Fast water-exchange Gd3+-(DO3A-like) complex functionalized with Aza-15-crown-5 showing prolonged residence lifetime in vivo

Cong Li, Ying Xia Li, Ga Lai Law, Kwan Man, Wing Tak Wong, Hao Lei

Research output: Contribution to journalArticlepeer-review

Abstract

A bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k ex = 3.1 × 107 s-1) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic.

Original languageEnglish (US)
Pages (from-to)571-574
Number of pages4
JournalBioconjugate Chemistry
Volume17
Issue number3
DOIs
StatePublished - May 2006
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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