Fast measurement of blood T1 in the human jugular vein at 3 Tesla

Research output: Contribution to journalArticle

Abstract

Current T1 values for blood at 3T largely came from in vitro studies on animal blood or freshly drawn human blood. Measurement of blood T1 in vivo could provide more specific information, e.g., for individuals with abnormal blood composition. Here, blood T1 at 3T was measured rapidly (<1 min) in the internal jugular vein using a fast inversion-recovery technique in which multiple inversion time can be acquired rapidly due to constant refreshing of blood. Multishot EPI acquisition with flow compensation yielded high resolution images with minimum partial volume effect. Results showed T1 = 1852 ± 104 msec among 24 healthy adults, a value higher than for bovine blood phantoms (1584 msec at Hct of 42%). A second finding was that of a significant difference (P < 0.01) between men and women, namely T1 = 1780 ± 89 msec (n = 12) and T1 = 1924 ± 58 msec (n = 12), respectively. This difference in normal subjects is tentatively explained by the difference in Hct between genders. Interestingly, however, studies done on sickle cell anemia patients with much lower Hct (23 ± 3%, n = 10) revealed similar venous blood T1 = 1924 ± 82 msec, indicating other possible physical influences affecting blood T1. Magn Reson Med, 2011.

Original languageEnglish (US)
Pages (from-to)1297-1304
Number of pages8
JournalMagnetic resonance in medicine
Volume65
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • internal jugular vein
  • inversion recovery
  • sickle cell anemia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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