Fast implementations of reconstruction-based scatter compensation in fully 3D SPECT image reconstruction

Dan J. Kadrmas, Eric C. Frey, Seemeen S. Karimi, Benjamin M.W. Tsui

Research output: Contribution to journalArticlepeer-review


Accurate scatter compensation in SPECT can be performed by modelling the scatter response function during the reconstruction process. This method is called reconstruction-based scatter compensation (RBSC). It has been shown that RBSC has a number of advantages over other methods s of compensating for scatter, but using RBSC for fully 3D compensation has resulted in prohibitively long reconstruction times. In this work we propose two new methods that can be used in conjunction with existing methods to achieve marked reductions in RBSC reconstruction times. The first method, coarse- grid scatter modelling, significantly accelerates the scatter model by exploiting the fact that scatter is dominated by low-frequency information. The second method, intermittent RBSC, further accelerates the reconstruction process by limiting the number of iterations during which scatter is modelled. The fast implementations were evaluated using a Monte Carlo simulated experiment of the 3D MCAT phantom with 99mTc tracer, and also using experimentally acquired data with 201Tl tracer. Results indicated that these fast methods can reconstruct, with fully 3D compensation, images very similar to those obtained using standard RBSC methods, and in reconstruction times that are an order of magnitude shorter. Using these methods, fully 3D iterative reconstruction with RBSC can he performed well within the realm of clinically realistic times (under 10 minutes for 64 x 64 x 24 image reconstruction).

Original languageEnglish (US)
Pages (from-to)857-873
Number of pages17
JournalPhysics in medicine and biology
Issue number4
StatePublished - Apr 1998
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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