TY - JOUR
T1 - Fast, hungry and unstable
T2 - finding the Achilles' heel of small-cell lung cancer
AU - Hann, Christine L.
AU - Rudin, Charles M.
N1 - Funding Information:
This work was supported by an American Society of Clinical Oncology Young Investigator Award (CLH), the Flight Attendant Medical Research Institute (CMR) and the Burroughs Wellcome Fund (CMR).
PY - 2007/4
Y1 - 2007/4
N2 - Over 95% of patients with small-cell lung cancer (SCLC) die within five years of diagnosis. The standard of care and the dismal prognosis for this disease have not changed significantly over the past 25 years. Some of the characteristics of SCLC that have defined it as a particularly virulent form of cancer - rapid proliferation, excessive metabolic and angiogenic dependence, apoptotic imbalance and genetic instability - are now being pursued as tumor-specific targets for intervention both in preclinical and early phase clinical studies. Here, we summarize areas of ongoing anti-cancer drug development, including classes of agents that target essential pathways regulating proliferation, angiogenesis, apoptotic resistance, chromosomal and protein stability, and cell-cell and cell-matrix interaction.
AB - Over 95% of patients with small-cell lung cancer (SCLC) die within five years of diagnosis. The standard of care and the dismal prognosis for this disease have not changed significantly over the past 25 years. Some of the characteristics of SCLC that have defined it as a particularly virulent form of cancer - rapid proliferation, excessive metabolic and angiogenic dependence, apoptotic imbalance and genetic instability - are now being pursued as tumor-specific targets for intervention both in preclinical and early phase clinical studies. Here, we summarize areas of ongoing anti-cancer drug development, including classes of agents that target essential pathways regulating proliferation, angiogenesis, apoptotic resistance, chromosomal and protein stability, and cell-cell and cell-matrix interaction.
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U2 - 10.1016/j.molmed.2007.02.003
DO - 10.1016/j.molmed.2007.02.003
M3 - Review article
C2 - 17324626
AN - SCOPUS:33947632458
SN - 1471-4914
VL - 13
SP - 150
EP - 157
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 4
ER -