Fast, hungry and unstable: finding the Achilles' heel of small-cell lung cancer

Christine L. Hann, Charles M. Rudin

Research output: Contribution to journalReview articlepeer-review

Abstract

Over 95% of patients with small-cell lung cancer (SCLC) die within five years of diagnosis. The standard of care and the dismal prognosis for this disease have not changed significantly over the past 25 years. Some of the characteristics of SCLC that have defined it as a particularly virulent form of cancer - rapid proliferation, excessive metabolic and angiogenic dependence, apoptotic imbalance and genetic instability - are now being pursued as tumor-specific targets for intervention both in preclinical and early phase clinical studies. Here, we summarize areas of ongoing anti-cancer drug development, including classes of agents that target essential pathways regulating proliferation, angiogenesis, apoptotic resistance, chromosomal and protein stability, and cell-cell and cell-matrix interaction.

Original languageEnglish (US)
Pages (from-to)150-157
Number of pages8
JournalTrends in Molecular Medicine
Volume13
Issue number4
DOIs
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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