Fast EPR imaging at 300 MHz using spinning magnetic field gradients

Yuanmu Deng, Guanglong He, Sergy Petryakov, Periannan Kuppusamy, Jay L. Zweier

Research output: Contribution to journalArticle


Electron paramagnetic resonance imaging (EPRI) technology has rapidly progressed in the last decade enabling many important applications in the fields of biology and medicine. At frequencies of 300-1200MHz a range of in vivo applications have been performed. However, the requisite imaging time duration to acquire a given number of projections, limits the use of this technique in many in vivo applications where relatively rapid kinetics occur. Therefore, there has been a great need to develop approaches to accelerate EPRI data acquisition. We report the development of a fast low-frequency EPRI technique using spinning magnetic field gradients (SMFG). Utilizing a 300MHz CW (continuous wave) EPRI system, SMFG enabled over 10-fold accelerated acquisition of image projections. 2D images with over 200 projections could be acquired in less than 3s and with 20s acquisitions good image quality was obtained on large aqueous free radical samples. This technique should be particularly useful for in vivo studies of free radicals and their metabolism.

Original languageEnglish (US)
Pages (from-to)220-227
Number of pages8
JournalJournal of Magnetic Resonance
Issue number2
StatePublished - Jun 2004
Externally publishedYes



  • Fast EPR imaging
  • Fast magnetic resonance imaging
  • Free radicals
  • Image reconstruction
  • Spinning magnetic field gradient
  • Trityl

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Deng, Y., He, G., Petryakov, S., Kuppusamy, P., & Zweier, J. L. (2004). Fast EPR imaging at 300 MHz using spinning magnetic field gradients. Journal of Magnetic Resonance, 168(2), 220-227.