Fast axonal transport in motor nerve regeneration

J. W. Griffin, Daniel B Drachman, D. L. Price

Research output: Contribution to journalArticle

Abstract

This report describes the fast axonal transport of [3H] leucine labeled proteins in regenerating rat sciatic motor nerves. A normal rate of fast transport (383±33 mm/day) was present in the regenerating sprouts, as well as in the central stumps. The rapidly transported proteins passed the level of axotomy without impediment, and accumulated in the endings of the regenerating sprouts, as shown by electron microscope autoradiography. In addition, transported proteins accumulated in terminal neuromas. The relative amount of protein incorporated radioactivity in the crest of fast transport in the regenerating nerves was increased compared to control nerves. These results are interpreted to suggest that the mechanism of fast transport is the same in regenerating sprouts as in normal axons; during regeneration fast transport appears to add newly synthesized materials to the growing tip.

Original languageEnglish (US)
Pages (from-to)355-370
Number of pages16
JournalJournal of Neurobiology
Volume7
Issue number4
StatePublished - 1976

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Nerve Regeneration
Axonal Transport
Proteins
Neuroma
Axotomy
Sciatic Nerve
Autoradiography
Leucine
Radioactivity
Axons
Regeneration
Electrons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fast axonal transport in motor nerve regeneration. / Griffin, J. W.; Drachman, Daniel B; Price, D. L.

In: Journal of Neurobiology, Vol. 7, No. 4, 1976, p. 355-370.

Research output: Contribution to journalArticle

Griffin, JW, Drachman, DB & Price, DL 1976, 'Fast axonal transport in motor nerve regeneration', Journal of Neurobiology, vol. 7, no. 4, pp. 355-370.
Griffin, J. W. ; Drachman, Daniel B ; Price, D. L. / Fast axonal transport in motor nerve regeneration. In: Journal of Neurobiology. 1976 ; Vol. 7, No. 4. pp. 355-370.
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